Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients: A Scalable and Sustainable Model
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,500
- 主要终点
- Vaccination Offer Rate
研究概览
简要总结
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
The study targets adult and elderly patients with chronic diseases or immunocompromising conditions who are eligible for vaccination according to national immunization guidelines. Vaccination is actively proposed during outpatient visits, hospital admissions, or at discharge and, when accepted, administered within the hospital or coordinated with local public health vaccination services.
The study aims to evaluate the feasibility, uptake, and completion of hospital-based vaccination pathways and to support integration between hospital and territorial prevention services for vulnerable populations.
详细描述
Vaccination coverage among hospitalized and chronically ill patients remains suboptimal despite strong national and international recommendations. Hospital settings represent a strategic opportunity to identify vulnerable patients, reduce missed vaccination opportunities, and improve access to preventive services.
AMBU-VAX is a prospective observational study conducted at Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome. The study targets adult patients affected by chronic diseases or immunocompromising conditions eligible for recommended vaccinations according to the Italian National Immunization Plan 2023-2025.
Patients are identified during outpatient visits, hospital admissions, or at discharge. Vaccination is actively proposed and, when accepted, administered within the hospital vaccination clinic or ward. When appropriate, patients are referred to local vaccination services to complete their immunization schedule.
Primary outcomes include vaccination offer, vaccine uptake, number of administered doses, and completion of vaccination pathways within the hospital setting. Secondary outcomes include reasons for vaccine refusal and referral to territorial vaccination services.
The study aims to assess the feasibility, effectiveness, and sustainability of a hospital-based vaccination model that can be replicated in other healthcare settings.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged ≥18 years
- •Presence of at least one chronic or immunocompromising condition eligible for vaccination according to national guidelines
- •Written informed consent provided
排除标准
- •Age <18 years
- •Conditions not included among the predefined eligibility criteria
结局指标
主要结局
Vaccination Offer Rate
时间窗: 12 months
Proportion of patients evaluated by the vaccination service who are offered at least one recommended vaccination.
Vaccination Uptake Rate
时间窗: 12 months
Proportion of patients who receive at least one vaccination among those evaluated.
Number of Administered Vaccine Doses
时间窗: 12 months
Number of doses administered by vaccine type
Completion of Hospital-Based Vaccination Pathway
时间窗: 12 months
Proportion of patients completing all scheduled vaccine doses within the hospital setting.
次要结局
- Reasons for Vaccine Refusal(12 months)
- Referral to Territorial Vaccination Services(12 months)
- Specialist Evaluation for Contraindications(12 months)