Acute Consumption of Breakfast Meals With Black Walnut, English Walnuts, or no Nuts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Change in triglycerides (TG) and glucose responses
研究概览
简要总结
Walnuts are a nutrient dense food, but most health research is on English walnuts (EW). Black walnuts (BW) contain a different antioxidant and fatty acid profile, and more protein, compared to EW. The purpose of the study was to compare postprandial responses following the consumption of 3 breakfast meals containing either butter (control), BW, or EW.
详细描述
This study was a randomized, double-blind control trial consisting of 3 study visits for 3 different treatments. The treatments were high-fat breakfast muffins containing either butter (control), black walnuts, or English walnuts. The investigators recruited healthy, normal-weight adults between the ages of 15 and 45y. Study visits were completed in a random order with at least 72 hours between each visit. Anthropometrics, questionnaires, and fasting and postprandial blood samples were collected at each visit.
Hypothesis
The walnut-containing meals would mitigate post-meal increases in glucose, insulin, triglycerides (TG), and lipid peroxidation while improving all measures of subjective appetite and TAC compared to the traditional meal without nuts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult men and women
- •Normal-weight (body mass index = 18-24.9kg/m2)
排除标准
- •Allergies to test meal ingredients (gluten, eggs, or nuts)
- •Medication/supplement usage
- •Chronic disease
- •Pregnancy or plans to become pregnant
- •Special diets
- •Tobacco use
结局指标
主要结局
Change in triglycerides (TG) and glucose responses
时间窗: Change from baseline to 3 hours postprandially
TG (mg/dL) and glucose (mg/dL)
Change in total antioxidant capacity
时间窗: Change from baseline to 3 hours postprandially
Total antioxidant capacity (uM trolox equivalents) measured via Oxygen Radical Absorbance Capacity (ORAC) assay.
Change in lipid peroxidation
时间窗: Change from baseline to 3 hours postprandially
Malondialdehyde (MDA) (uM) measured via Thiobarbituric acid reactive substances (TBARS) assay
Change in insulin
时间窗: Change from baseline to 3 hours postprandially
Insulin (uU/mL)
次要结局
- Change in angiopoietin-like proteins-3 (ANGPTL3) and -4 (ANGPTL4) responses(Change from baseline to 3 hours postprandially)
- Change in hunger and satiety responses(Change from baseline to 3 hours postprandially)
研究者
Jamie Cooper, PhD
Professor and Director of UGA Obesity Initiative
University of Georgia