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临床试验/NCT05797389
NCT05797389尚未招募不适用

Effects of Graft Vascular Dimensions on Perioperative Surgical and Functional Outcomes of Living Donor Kidney Transplantation in Pediatrics and Adults: A Prospective Case Series

Assiut University0 个研究点目标入组 30 人开始时间: 2023年4月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
主要终点
2- Rate of decline of the serum creatinine level.

研究概览

简要总结

  1. Correlate the radiological and intraoperative measuring of the vascular dimensions,
  2. Assess the effect of the vascular dimensions on the short-term surgical complications and
  3. Assess the effect of the vascular dimensions on the primary graft function in pediatric and adults KTs.

详细描述

Vascular complications after kidney transplantation (KT) are variably rare with an incidence of 3-15%. They are a significant and most serious part of surgical complications of KT. They may acutely result in graft loss during surgery or early in the perioperative period and may threaten patient's life. The most common forms of early vascular complications are haemorrhage, hematomas, arterial or venous thrombosis, arterial vasospasm, and arterial intimal dissection. In pediatric and adult KT, most studies addressing the vascular complications followed a common attitude of estimating the prevalence and management of these complications rather than studying the predisposing factors. Specifically, studying the normal and abnormal anatomy of the grafts has mainly been directed towards the number of graft vessels. However, there are many other vascular parameters that may potentially influence the outcome of vascular anastomosis and therefore the graft and patient outcomes. To the best of the investigators knowledge, the vascular dimensions of the renal and iliac vessels, such as the length, diameter and site of anastomosis to the iliac vessels have not been studied before so the investigators hypothesis that these dimensions can unequally affect the outcomes of surgery and early graft function in KTs. Hence, this study will be conducted to assess the effects of the vascular dimensions on the outcomes of surgery and primary graft function in pediatric versus adult living donor KT.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Pediatric and adult patients undergoing living donor kidney transplantation.

排除标准

  • Patients with acute graft rejection occurring within the first week of transplantation.
  • Patients refusing participation in the study.

结局指标

主要结局

2- Rate of decline of the serum creatinine level.

时间窗: one month post operative.

2- Rate of decline of the serum creatinine level.

Mode of graft function defined by: 1- the time of start of diuresis post-transplantation.

时间窗: one month post operative.

Mode of graft function defined by: 1- the start of diuresis (sufficient amount of urine production) within one hour of declamping through the first week post-transplantation

次要结局

  • The rate of vascular complications (intra- or perioperative).(one month post operative)
  • The rate of other surgical complications.(one month post operative)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohamed Loay

Assistant lecturer

Assiut University

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