Clinical Recruitment of Patients With First-line Targeted Drug Resistance or Intolerance to Hepatocellular Cancer With PD-1 Inhibitor (Toripalimab,JS001) Detected on the NGS Platform Combined With Anlotinib
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Objective response rate
研究概览
简要总结
PD-1 inhibitors have become the standard treatment for advanced hepatocellular cancer, while targeted drugs such as sorafenib and lenvatinib are the first-line standard treatment for hepatocellular cancer. Recent studies have shown that PD-1 inhibitors combined with targeted drugs can improve the efficacy of hepatocellular cancer.To clear the joint treatment in patients with advanced hepatocellular cancer (HCC) efficacy and evaluate its safety, we proposed to carry out the PD - 1 inhibitor (Toripalimab, JS001) joint anti-angiogenesis small molecules targeting drug anlotinib for clinical research,at the same time, based on joint solution of NGS platform testing to predict the curative effect, bring benefit for the long-term survival of patients with hepatocellular cancer (HCC).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological or cytological diagnosis of hepatocellular cancer;
- •At least one measurable lesion was assessed according to RECIST1.1 criteria.
- •Age from 18 to 75,ECOG physical strength score reaches 0-2;
- •After first-line targeted therapy, it was assessed as advanced or intolerant according to RECIST1.1 criteria.
- •Child-pugh grade A or B for liver function;
- •Bone marrow function was basically normal: neutrophils > 1.5x 10^9/L, platelets > 75 x10^9/L;
- •Adequate renal reserve: creatinine <130 mol/L;
- •Centerless dysfunction, chest pain (medically uncontrollable), no myocardial infarction within 12 months prior to study initiation;
- •Estimated survival ≥3 months;
- •Signed the informed consent.
排除标准
- •Previous application of PD-1 inhibitor and anlotinib;
- •Secondary malignant tumors or other tumors (except superficial skin cancer and localized low-grade malignant tumors) occurring within 3 years prior to the start of the study;
- •Metastasis of the brain or meninges;
- •Imaging findings indicated that the tumor was involved in important blood vessels or that the researchers had assessed that it might lead to fatal bleeding during follow-up;
- •Bleeding events at any site ≥CTCAE level 3 occurred 4 weeks before medication, and there were unhealed wounds, ulcers or fractures;
- •The time of occurrence of arteriovenous thrombosis, such as cerebrovascular accident, deep vein thrombosis and pulmonary embolism, within 6 months before enrollment;
- •Untreated intestinal obstruction or subobstruction that cannot eat or affect systemic administration;
- •Patients with active infection or other possible disorders receive inflammatory infections under planned management;
- •Have a history of uncontrolled substance abuse or mental disorders;
- •In the judgment of the investigator, patients with concomitant diseases that may seriously endanger their own safety or may affect the completion of the study;
- •Participated in other clinical trials;
- •Pregnant and nursing women;
研究组 & 干预措施
Anlotinib and Toripalimab treatment
Anlotinib Hydrochloride and Toripalimab Injection
干预措施: Anlotinib;Toripalimab (Drug)
结局指标
主要结局
Objective response rate
时间窗: at least 2 months
Objective response rate include response from stable disease to complete
次要结局
- Progression-free survival(at least 2 months)
研究者
Shen Feng
Director of Oncology Department
Eastern Hepatobiliary Surgery Hospital