A Phase II Study Of BIBF 1120 as Second-line Treatment for Patients With Small Cell Lung Cancer
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Overall response rate
研究概览
简要总结
Although chemotherapy is the primary treatment option for small cell lung cancer (SCLC), longterm survival is rare. SCLC is initially chemosensitive, but rapidly relapses in a chemoresistant form with an overall survival of <5%. Consequently, novel therapies are urgently required and will likely arise from an improved understanding of the disease biology. Some preclinical studies have showed that fibroblast growth factor-2 induces proliferation and
详细描述
Chemotherapy is the primary treatment option for patients with small cell lung cancer (SCLC), leading to a 5-year survival of about 20% in limited disease (LD), and less than 5% in extensive disease (ED). Although initial tumor response rate to chemotherapy is very high (up to 96% for LD and up to 65% in ED), SCLC relapses in approximately 4 months in ED and 12 months in LD. Despite the administration of second-line chemotherapy, the overall median survival of patients with limited and extensive disease is approximately 18 and 9 months, respectively. In the setting of second-line therapy, response rates to chemotherapy range between 15 and 25%, with median survival in the range of 4-6 months. Second-line therapeutic options include cyclophosphamide, doxorubicin and vincristine (CAV) given every 3 weeks or topotecan, which have similar response rates, time to progression and survival in the two treatment arms (topotecan 24%, 13 and 24.7 weeks; CAV 18%, 12 and 22 weeks, respectively). However, both treatments have substantial toxicities, with 9% of patients on trial withdrawing for toxicity reasons. Treatment-associated mortality was as high as 4.7% (possibly and definitely related), and many patients required transfusion support. Thus, while these treatments have acceptable activity second-line, more active and less toxic treatments are required for this patient population.
The next generation of anti-angiogenic drugs aims to improve clinical efficacy by targeting multiple angiogenic factors. This approach was validated by a recent analysis of BIBF 1120, which inhibits vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and the fibroblast growth factor receptors (FGFRs). BIBF 1120 resulted in growth inhibition of tumours in syngeneic rats and human tumour xenografts in nude mice. It also displayed a favourable cellular duration of action and pharmacodynamic profile and was well-tolerated. These data complement early-phase clinical data suggesting that BIBF 1120 might be an effective anti-angiogenic agent. Some preclinical studies have showed that fibroblast growth factor-2 induces proliferation and chemoresistance in SCLC cells. In addition, the selective fibroblast growth factor receptor (FGFR) inhibitor PD173074 blocks H-510 and H-69 SCLC proliferation and clonogenic growth in a dose-dependent fashion and prevents FGF-2-induced chemoresistance. BIBF1120 is a novel, orally available, potent triple angiokinase inhibitor that predominantly blocks the FGFR in addition to vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGFR). Therefore, the investigators will conduct a phase II trial to evaluate the efficacy of BIBF1120 in patients with recurrent SCLC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed SCLC
- •Progression during or after prior first line chemotherapy.
- •At least one target tumor lesion RECIST 1.1)
- •Life expectancy of at least three months
- •ECOG PS 0-2
- •Written informed consent
排除标准
- •Previous therapy with other VGFR inhibitors (other than bevacizumab)
- •Persistence of clinically relevant therapy related toxicities from previous chemotherapy and/or radiotherapy
- •Chemo-, hormone-, immunotherapy with monoclonal antibodies, treatment with tyrosine kinase inhibitors, or radiotherapy (except for brain and extremities) within the past 3 weeks prior to treatment with the trial drug i.e., the minimum time elapsed since the last anticancer therapy and the first administration of BIBF 1120 must be 3 weeks
- •Treatment with other investigational drugs or treatment in another clinical trial within the past three weeks before start of therapy or concomitantly with this trial
- •Concomitant yellow fever vaccination
- •Uncontrolled brain metastases, spinal cord compression, carcinomatous meningitis, or leptomeningeal disease. Patients should have completed surgery or radiation therapy for existing brain metastases, should not have documented increase in size over the previous 3 months and should be asymptomatic off steroids
- •Radiographic evidence of cavitary or necrotic tumors
- •Centrally located tumors with radiographic evidence (CT or MRI) of local invasion of major blood vessels
- •History of clinically significant haemoptysis within the past 3 months (more than one teaspoon of fresh blood per day)
- •Therapeutic anticoagulation (except low dose heparin and/or heparin flush as needed for maintenance of an indwelling intravenous device) or antiplatelet therapy (except for chronic low-dose therapy with acetylsalicylic acid ≤325mg per day)
- •History of major thrombotic or clinically relevant major bleeding event in the past 6 months
- •Known inherited predisposition to bleeding or thrombosis
- •Significant cardiovascular diseases (i.e., hypertension not controlled by medical therapy, unstable angina, history of myocardial infarction within the past 12 months, congestive heart failure > NYHA II, serious cardiac arrhythmia, pericardial effusion)
- •Calculated creatinine clearance by Cockcroft Gault <45ml/min
- •Proteinuria CTCAE grade 2 or greater
- •Total bilirubin above the upper limit of normal
- •ALT and/or AST > 2.5 x upper limit of normal in the presence of live metastasis or ALT and/or AST >1.5 x upper limit of normal in patients without liver metastasis.
- •Prothrombin time and/or partial thromboplastin time greater than 50% deviation from normal limits
- •Platelets <100000 platelets/μL (=mm3)
- •Significant weight loss (> 10 %) within the past 6 weeks prior to treatment in the present trial
- •Current peripheral neuropathy ≥ CTCAE(version4.0) Grade 2 except due to trauma
- •Pre-existing ascites and/or clinically significant pleural effusion
- •Major injuries and/or surgery within the past ten days prior to randomization with incomplete wound healing
- •Serious infections requiring systemic antibiotic (e.g. antiviral, antimicrobial, antifungal) therapy
- •Gastrointestinal disorders or abnormalities that would interfere with absorption of the study drug
- •Active or chronic hepatitis C and/or B infection
- •Known human immunodeficiency virus (HIV) seropositivity
- •serious illness or concomitant non-oncological disease or
- •Pregnancy or breast feeding
- •Active alcohol or drug abuse
- •Other malignancy within the past three years
- •Hypersensitivity to BIBF 1120 and/or the excipients of the trial drugs
研究组 & 干预措施
study arm
BIBF 1120 study arm
干预措施: BIBF 1120 (Drug)
结局指标
主要结局
Overall response rate
时间窗: every 8 weeks
To assess the efficacy of BIBF1120 as second-line treatment in patients with recurrent small cell lung caner
次要结局
- Overall survival rate(every 8 weeks)
- Progression free survival(every 8 weeks)
- Toxicity(every 4 weeks)
研究者
Ji-youn Han
Head, Center for Lung Cancer
National Cancer Center, Korea