Effect of intracuff Inflation with Normal Saline versus 2 percentage Lignocaine versus 0.75 percentage Ropivacaine on the incidence of Post-Operative Sore Throat in patients undergoing General Anaesthesia with Endotracheal intubation - A Randomized Controlled Trial.

Post-operative sore throat (POST) is a common and often underestimated complication following general anesthesia with endotracheal intubation, affecting 20% to 74% of patients. Traditional air-filled endotracheal tube cuffs can lead to increased cuff pressure due to anesthetic gas diffusion, contributing to tracheal mucosal irritation and POST. Using fluid media such as normal saline or local anesthetics like 2% lignocaine and 0.75% ropivacaine for cuff inflation may help stabilize cuff pressure and provide localized analgesia. While lignocaine has been widely studied and shown to reduce POST, limited data exist on the use of ropivacaine, despite its longer duration of action and favorable safety profile. This study aims to compare the effectiveness of intracuff 2% lignocaine versus 0.75% ropivacaine in reducing the incidence and severity of POST, potentially offering improved strategies for enhancing patients comfort after surgery.