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临床试验/NCT06662513
NCT06662513尚未招募不适用

An Australian Regional Hospital's Oesophagectomy Outcomes

Launceston General Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2024年11月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
100
试验地点
1
主要终点
mortality

研究概览

简要总结

Literature review/rationale for project

  • Oesophageal cancer is associated with a grim prognosis despite many advances in treatment. Oesophagectomy is a key component of the care of patients who are candidates for curative treatment, however it is associated with substantial morbidity.
  • Several studies have suggested that oesophagectomies performed at higher volume tertiary centres are associated with lower morbidity and mortality than lower volume centres, and this has prompted changes to policy in countries such as Great Britain, Canada and the Netherlands with regards to the centralisation of these cases. A higher volume centre within Australia is likely to perform 6 or more procedures per year.
  • Currently within Australia, centralisation on a large scale has not occurred. This has been limited in part by resource provision and geographical barriers. Therefore, oesophagectomies in Australia are still routinely performed in regional centres. However, there is a paucity of recent outcomes data from these centres.

Aims/objectives

  • Retrospective review of oesophagectomies undertaken in a single regional centre in Tasmania, Australia over 10 years (January 2014 to December 2023)
  • Assess outcomes (long and short-term complications and mortality) and compare to morbidity and mortality rates from larger international centres

详细描述

Research aims/objectives

  • Retrospective review of oesophagectomies undertaken in a single regional centre in Tasmania, Australia over 10 years (January 2014 to December 2023)
  • Assess outcomes (long and short-term complications, mortality, survival) and compare to published outcomes from larger national and international centres

Project Design Research project setting: Launceston General Hospital (Tasmania, Australia)

Methodological approach: Retrospective case series

Participants

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • patients who underwent oeophagectomy at Launceston General Hospital between January 2014 to December 2023

排除标准

  • 未提供

结局指标

主要结局

mortality

时间窗: from date of surgery to end of study (November 2024) for a timeframe up to 10 years

date of death from any cause or date of palliation whichever came first

Anastomotic leak

时间窗: from date of surgery to end of study period (Nov 2024), assessed up to 10 years

Grade 1-3, diagnosed radiologicaly, requiring intervention (surgical or non-surgical)

Length of stay

时间窗: from date of surgery to discharge date of hospital admission, approximately 2-4 weeks in most cases but assessed up to 12 weeks

total inpatient hospital stay and total ICU length stay

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Renishka Sellayah

Principal investigator

Launceston General Hospital

研究点 (1)

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