Effects of Conventional Versus Acupuncture-like TENS on Pain Threshold and Brain Activities in Healthy Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- EEG power spectrum change in delta band after the intervention
研究概览
简要总结
The purpose of this study was to understand the effects of conventional versus acupuncture-like TENS on pain threshold, brain activities, and their relationships.
详细描述
Transcutaneous electrical nerve stimulation (TENS) is a pain modulation tool which is commonly used clinically. TENS has 2 major modes: "conventional TENS'' and "acupuncture like TENS". Conventional TENS induces a local pain modulation, whereas acupuncture like TENS induces central pain modulation mechanism. The pain threshold at treatment area and outside of area is regarded as local pain modulation and central pain modulation respectively. However, the effect of acupuncture like TENS on pain threshold was remained unclear. TENS also induces cortical activities changed in the central nervous system. Recent Electroencephalography (EEG) studies suggested that TENS induces event-related potential and power spectrum changes, however, the time and frequency bands of EEG changes and its relationship with pain threshold were still unclear. Therefore, the purpose of this study was to understand the effects of conventional versus acupuncture-like TENS on pain threshold, brain activities, and their relationships.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20~65 y adults
- •No cognitive function problem
- •Without taking any type of pain medication or substances that could affect the cognitive functions
排除标准
- •Peripheral or central nervous system disease
- •Sensory lose
- •TENS application is contraindication
- •Cardiac pacemaker
- •Any type of pain
结局指标
主要结局
EEG power spectrum change in delta band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
Pressure pain tolerance after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Use a pressure algometer to press on the first dorsal interosseous muscle and the pressure would stop until the feeling reach the pain intensity at 5/10.
EEG power spectrum change in beta band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
EEG power spectrum change in total gamma band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
EEG power spectrum change in alpha band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
EEG power spectrum change in low-gamma band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
EEG power spectrum change in high-gamma band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
Pressure pain threshold after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Use a pressure algometer to press on the first dorsal interosseous muscle and the pressure would stop until the feeling changes from non-painful feeling to painful feeling.
EEG power spectrum change in theta band after the intervention
时间窗: The change between baseline and the time after 30 minutes intervention
Evaluate brain activity after the intervention
次要结局
- EEG power spectrum change in theta band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in alpha band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- Pressure pain tolerance after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- Pressure pain threshold after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in delta band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in beta band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in high-gamma band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in low-gamma band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)
- EEG power spectrum change in total gamma band after the 30 minutes break(The change between 30 minutes intervention and 30 minutes break after the intervention)