Evaluation of Usefulness of Bisphosphonate for diffuse sclerosing osteomyelitis of the jaw - Evaluation of Usefulness of Bisphosphonate for diffuse sclerosing osteomyelitis of the jaw

Kitagawa Yoshimasa0 个研究点目标入组 13 人开始时间: 2018年11月16日最近更新: 2023年10月17日

适应症

试验速览

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•Patients suspected diffuse sclerosing osteomyelitis of jaw clinically in Hokkaido university hospital. The final diagnosis of DSO is determined as follows in the conference by oral surgery specialist.
•1Recurrent pain and swelling of the mandible, with no sign of infection with microorganisms.
•2CT images of DSO patients showed an intermingled sclerotic and lytic pattern in the cortex and medulla.
•3Antimicrobial treatment has not proved to be effective.
•4No history of irradiation to the maxillofacial area and received long-term bisphosphonate therapy.
•Inclusion Criteria
•1over 15 years old
•2written informed consent
•3Performance Status 0 or 1

•1)Patients diagnosed Anti-resorptive agents-related ONJ
•2)Patients who received other bisphosphonate.
•3)Children of 15 years or under.
•4)pregnancy, nursing woman or possibly pregnant woman.
•5)Patients with severe renal disorders(BUN:=<1.5 upper limit of normal,Cr:=<1.5 upper limit of normal)
•6)patients who are contraindications for Voltaren
•7)patient that physician determined inappropriate.

发起方

Kitagawa Yoshimasa