Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- HADS score
研究概览
简要总结
The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
详细描述
Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 18 years old
- •Diagnosed as herpes zoster neuralgia
- •Signing informed consent
排除标准
- •Unable to complete the scale assessment
- •History of mental illness
结局指标
主要结局
HADS score
时间窗: during hospital stay, average of 1 week
Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression.
次要结局
- Interleukin (IL）-1β plasma level(during hospital stay, average of 1 week)
- C-reactive protein (CRP) plasma level(during hospital stay, average of 1 week)
- Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging(during hospital stay, average of 1 week)
- IL-2 receptor plasma level(during hospital stay, average of 1 week)
- IL-10 plasma level(during hospital stay, average of 1 week)
- Interferon(INF)-α plasma level(during hospital stay, average of 1 week)
- IL-8 plasma level(during hospital stay, average of 1 week)
- IL-6 plasma level(during hospital stay, average of 1 week)
- Brain-derived neurotrophic factor (BDNF) plasma level(during hospital stay, average of 1 week)
研究者
Wei Mei
Deputy director of anesthesiology
Huazhong University of Science and Technology