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临床试验/NCT06841809
NCT06841809已完成不适用

The Role of Radiographic Indices in the Evaluation of Hand and Wrist Pathologies in Patients With Carpal Tunnel Syndrome

Ankara Training and Research Hospital1 个研究点 分布在 1 个国家目标入组 275 人开始时间: 2025年2月16日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
275
试验地点
1
主要终点
Measurement of Radiographic Indices

研究概览

简要总结

The aim of this study was to compare wrist radiographic indices in patients with idiopathic carpal tunnel syndrome (CTS) with normal cases. The investigators believe that the investigators can contribute to the development of new treatment strategies by determining the radiographic features that contribute to the development of CTS.

详细描述

Carpal tunnel syndrome (CTS) is the most common mononeuropathy of the upper extremity. It occurs as a result of compression of the median nerve in the carpal tunnel during its course in the wrist. Clinical symptoms are characterized by numbness and tingling in the first 3 fingers and the radial half of the 4th finger, which are compatible with the distribution of the median nerve. Electrophysiologically, it is classified as mild, moderate and severe. As the disease duration increases, atrophy and weakness may develop in the thenar muscles. The incidence is 4-5% worldwide and is more common in women between the ages of 40-60.

Pathophysiology consists of mechanical compression, increased pressure, ischemia in the median nerve and local metabolic changes.

Among the risk factors, occupations that require repeated flexion and extension of the wrist constitute environmental risk factors. Extension can increase the tunnel pressure by 10 times, while flexion can increase it by more than 8 times. Systemic risk factors for CTS are pregnancy, menopause, obesity, renal failure, hypothyroidism, oral contraceptive use, and congestive heart failure.

Diabetes, alcoholism, vitamin deficiency or toxicity, and exposure to toxins are neuropathic risk factors. Localized risk factors include mass lesions that compress the tunnel, arthritis, and radius distal end fractures.

Despite these risk factors, most cases of CTS are still classified as idiopathic.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Not having had any previous surgical procedures on the hand or wrist
  • •Not having had a major hand or wrist trauma
  • •No structural disorders in the bone structure

排除标准

  • •Being under 18 years of age
  • •History of major hand-wrist trauma or surgery
  • •Acromegaly
  • •Rheumatoid arthritis
  • •Systemic lupus erythematosus
  • •GUT arthritis
  • •Psoriatic arthritis

结局指标

主要结局

Measurement of Radiographic Indices

时间窗: up to 12 weeks

Radio-lunate Angle (RLA): The distance between the tangential line connecting the two distal poles of the lunate root and the line drawn perpendicular to the central medullary canal of the distal radius.

次要结局

  • Boston Carpal Tunnel Syndrome Questionnaire(up to 12 weeks)
  • Electromyography Examination(up to 12 weeks)
  • Measurement of Radiographic Indices(up to 12 weeks)

研究者

发起方
Ankara Training and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Nadide Koca

Principal Investigator

Ankara Training and Research Hospital

研究点 (1)

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