Clinical Determinants of Handgrip Strength in Critically Ill Adults: Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- To determine the feasibility of performing serial assessments of strength (handgrip and limb muscle strength) in a broad population of critically ill patients.
研究概览
简要总结
To better understand ICU-acquired weakness in patients requiring mechanical ventilation in the Intensive Care Unit.
详细描述
We have generated the hypothesis that handgrip strength can be used to develop our understanding of the effects of critical illness on peripheral muscle strength.
To begin to develop this hypothesis, a better understanding of the determinants of handgrip strength needs to be developed. As a result we propose to perform a prospective observational study examining the clinical factors that are associated with handgrip strength. Several clinical factors are known to be associated with increased risk of developing ICUAP while hospitalized: multiple organ failure, severe sepsis, female gender and treatments like steroids. As many of these risk factors are not modifiable, the opportunity to intervene is unclear. However, by attempting to better describe the spectrum of strength deficits experienced by critically ill patients we may better be able to dissect and prevent ICUAP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Adult patients admitted to the Medical ICU
- •Age ≥ 18 years of age at ICU admit.
- •Requiring mechanical ventilation for at least 24 hours
排除标准
- •• Moribund or in the process of withdrawal of life support
- •Patient, family or physicians not in favor of continued support until awakening.
- •Profound neurologic injury associated with little or no chance of awakening.
- •Active consideration of a diagnosis of brain death by treating physicians.
- •Known history of chronic neurological disease resulting in muscle weakness in more than two limbs.
- •Inability to perform handgrip dynamometry prior to acute illness.
- •Subject is a Non-english speaker
- •Subject or surrogate unable to provide informed consent.
- •ICU stay of greater than 24 hours within the last thirty days or at any point during the current hospitalization
- •Greater than seven days of hospital care prior to hospital admission.
- •Greater than five days since inclusion criteria met.
结局指标
主要结局
To determine the feasibility of performing serial assessments of strength (handgrip and limb muscle strength) in a broad population of critically ill patients.
时间窗: duration of ICU stay-up to 10 days
次要结局
- To generate a set of normative data for handgrip strength in critically ill patients adjusting for important non-modifiable risk factors(duration of ICU stay-up to 10 days)
- To determine the acute medical illnesses associated with weakness(duration of ICU stay-up to 10 days)
- To determine the modifiable risk factors associated with weakness(duration of ICU stay-up to 10 days)
- To determine if there is an association between handgrip strength and ICUAP risk(duration of ICU stay-up to 10 days)
研究者
Naeem Ali, MD
Associate Professor
Ohio State University