Does Pregnancy Increase Risk of Ventral Hernia Recurrence?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3,578
- 主要终点
- Clinical Ventral Hernia (Epigastric, Umbilical and Incisional Hernia) Recurrence
研究概览
简要总结
The investigators will examine if pregnancy increases risk of ventral hernia recurrence
详细描述
The investigators will establish a cohort of female fertile patients who underwent ventral hernia repair (Umbilical, Epigastric and Incisional hernia repair) registered in the Danish Hernia Database. The investigators will link these data at an individual level with the Danish National Patient Registry (DNPR), Danish Medical Birth Registry (DMBR) and the Danish Civil Registry (CPR).
From DMBR, subsequent pregnancies in the study cohort will be noted. From DNPR, ventral hernia recurrence, defined as clinical recurrence and/or reoperation for recurrence will be noted. Cases registered with both clinical recurrence and reoperation for recurrence, the date of the earliest registration will be defined as the date of ventral hernia recurrence.
From CPR, date of death or emigration will be noted.
Through an extended Cox regression analysis, handling pregnancy as a time-dependent variable, the investigators will examine whether pregnancy is associated with an increased risk of ventral hernia recurrence.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 45 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Fertile female patient
排除标准
- •non-Danish citizen
结局指标
主要结局
Clinical Ventral Hernia (Epigastric, Umbilical and Incisional Hernia) Recurrence
时间窗: 0-7 years
Clinical ventral hernia recurrence will be defined as clinical recurrence retrieved from the Danish National Patient Registry.
Ventral Hernia (Epigastric, Umbilical and Incisional Hernia) Recurrence Repair
时间窗: 0-8 years
Ventral hernia recurrence repair will be defined as reoperation retrieved from the Danish National Patient Registry.
次要结局
未报告次要终点
研究者
Erling Oma
Research scholar
Bispebjerg Hospital