Da Qing Offspring Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Cumulative incidence rate of diabetes
研究概览
简要总结
This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Spouses of the original Daqing diabetes Prevention Research Population (IGT), offspring 1 to 3 generations, and offspring spouses were included in the study, without special restrictions on subjects' gender, age, basic disease status, etc。
- •Conduct a death agent investigation for some deceased members.
排除标准
- •▪People who are unwilling to participate in this study
结局指标
主要结局
Cumulative incidence rate of diabetes
时间窗: Through study completion, an average of about 1.5 years
This study statistically analyzed the cumulative incidence rate of diabetes at the end of the study through interview, medical record review, physical examination
次要结局
- weight(Through study completion, an average of about 1.5 years)
- Height(Through study completion, an average of about 1.5 years)
- Exercise frequency and intensity(Through study completion, an average of about 1.5 years)
- dietary habits(Through study completion, an average of about 1.5 years)
- waist circumference(Through study completion, an average of about 1.5 years)
- Coronary heart disease incidence(Through study completion, an average of about 1.5 years)
- cardiovascular mortality rate(Through study completion, an average of about 1.5 years)
- all-cause deaths(Through study completion, an average of about 1.5 years)
- incidence of diabetic peripheral neuropathy(Through study completion, an average of about 1.5 years)
- other cause mortality(Through study completion, an average of about 1.5 years)
- incidence of blindness(Through study completion, an average of about 1.5 years)
- Diabetic retinopathy incidence(Through study completion, an average of about 1.5 years)
- Diabetic nephropathy incidence(Through study completion, an average of about 1.5 years)
- Peripheral vascular disease incidence(Through study completion, an average of about 1.5 years)
- Heart failure incidence(Through study completion, an average of about 1.5 years)
- Stroke incidence(Through study completion, an average of about 1.5 years)
- health-related quality of life(Through study completion, an average of about 1.5 years)
- blood pressure(Through study completion, an average of about 1.5 years)
- blood sugar(Through study completion, an average of about 1.5 years)
- blood lipid(Through study completion, an average of about 1.5 years)
- skin AGE(Through study completion, an average of about 1.5 years)
- Tidal Volume(Through study completion, an average of about 1.5 years)
- Functional Residual Capacity(Through study completion, an average of about 1.5 years)
- Forced Vital Capacity(Through study completion, an average of about 1.5 years)
- Forced Expiratory Volume in 1 second(Through study completion, an average of about 1.5 years)
研究者
Bo Zhang
Professor
China-Japan Friendship Hospital