Effect of Treatment of Pre-induction Hypertension on Hemodynamic Stability During Induction of General Anesthesia

The investigators hypothesize that treatment of hypertension (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) with an IV short acting, calcium channel antagonist will (1) reduce excursions outside of a pre-specified blood pressure range and (2) reduce the requirement for exogenous vasopressor agents from the period of induction until incision in adults undergoing general anesthesia.

This is a single site, randomized, blinded, placebo controlled prospective trial during which the continuous intravenous administration of clevidipine or placebo will be administered to target a blood pressure in a specified normal range.

The trial will be performed by two investigators. The first investigator will work with the pre-operative nursing staff to identify patients in the pre-op waiting area who meet criteria for hypertension. Admission criteria to the study will be a systolic blood pressure in the Stage 2 category (between 140 mmHg and 180 mmHg or a diastolic blood pressure between 90 mmHg and 110 mmHg). These criteria are chosen based on the 2017 American Heart Association/American College of Cardiology guidelines where blood pressure greater than 180/110 mmHg is a hypertensive emergency and would prompt case cancellation and blood pressure < 140/90 mmHg would not require immediate pharmacological intervention.

Following an information session during which the consent document and the UCSD HIPPA form are reviewed, discussed and signed, participant will be assigned a study number and relevant baseline data will be collected from the patient's medical record including age, ASA classification, history of known cardiac, pulmonary, renal disease and home medications. Once consented, patients will be randomized into one of two groups using a block randomization table. The treatment arm will receive clevidipine and the control arm will receive a placebo solution (lactated Ringer's solution).

The investigator will start the appropriate drug and titrate the drug in the pre-operative area until the mean arterial pressure is between 70 mmHg and 110 mmHg. The infusion will be titrated every 90 seconds to a maximum rate 32 mg/hr for clevidipine (which is 64 ml/hr) or the volume equivalent of placebo. The investigator will measure the patient's vital signs every 3 minutes with initiation or change in infusion rate until the subject's mean arterial pressure is within the normal range and the subject is on a stable dose of the drug for two concurrent values. The dose will therefore be determined by the patient's response to the drug. This is not a dose-ranging or dose escalation study. After the blood pressure is stable, the investigator will measure and record the blood pressure every 15 minutes.