Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive CareAcronym: ASPIC - ASPIC

Assistance Publique - Hôpitaux de Paris0 个研究点目标入组 590 人开始时间: 2022年1月18日最近更新: 2022年1月24日

适应症

试验速览

暂无简介。

•Adult patient is =18 and
•- Patient under MV
•- Diagnosis of microbiologically confirmed of first episode of VAP
•- Initial adequate empiric antibiotic therapy
•-Written informed consent from the patient or a legal representative if appropriate. If absence of a legal representative the patient may be included in emergency procedure
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 590
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 590

•Patient under selective decontamination of the digestive tract
•- Concomitant extra-respiratory infection requiring antibiotic therapy at the moment of inclusion
•- Inclusion in another interventional study concerning antimicrobial strategies
•- Moribund (IGS II>80)
•- Thoracic trauma with Abbreviated Injury Scale (AIS) thorax ? 3
•- Severely immunocompromised patients (such as congenital immunodeficiency , neutropenia (<1leucocyte/ml or <0.5 neutrophil/ml) or acute hematologic malignancy or stem cell transplant, HIV infection with CD4 count below 200/mm3
•- VAP due to: Pseudomonas aeruginosa, Carbapenem-resistant Acinetobacter spp, Carbapenem-resistant Enterobacteriaceae
•- Bacterial VAP in a context of COVID-19 or other confirmed viral pneumonia
•- No health insurance coverage

发起方