NCT02407197已完成不适用
International T1 Multicentre CMR Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,629
- 试验地点
- 4
- 主要终点
- Survival
研究概览
简要总结
Myocardial fibrosis is the fundamental substrate for the development of heart failure.
Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping.
Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy.
Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE.
Primary endpoints: all cause and cardiovascular mortality.
Secondary endpoints: arrhythmic composite and HF composite endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults > 18 years of age
- •clinical indication for CMR
- •able to provide informed consent
- •Exclusion criteria:
- •contraindications for cardiac magnetic resonance imaging due to MR unsafe devices or objects
排除标准
- 未提供
结局指标
主要结局
Survival
时间窗: 1 year
number of deaths
次要结局
- Rate of deaths due to cardiovascular causes(1 year)
- Rate of HF events(1 year)
- Rate of Arrhythmia(1 year)
研究者
Eike Nagel
Global Chief Investigator
King's College London
研究点 (4)
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