Relationship Between Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- serum IgG, IgA, IgM
研究概览
简要总结
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
详细描述
descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Down Syndrome with acute bronchopneumonia
- •sufficient cognitive ability
排除标准
- •severe congenital heart defects
- •primary immunodeficiencies
结局指标
主要结局
serum IgG, IgA, IgM
时间窗: Upon enrollment and prior to any intervention baseline data were collected
Immunoglobulins: Concentrations of IgG(mg/dl) IgA,(mg/dl) and IgM (mg/dl) were determined from serum using an automated nephelometer
Respiratory Rate
时间窗: Upon enrollment and prior to any intervention baseline data were collected
Respiratory rate (breaths/minute) was determined by direct observation and counting of chest wall movements over one full minute
Arterial Oxygen Saturation (SaO2)
时间窗: Upon enrollment and prior to any intervention baseline data were collected
Peripheral oxygen saturation (%) was measured non-invasively via pulse oximetry
White Blood Cell count
时间窗: Upon enrollment and prior to any intervention baseline data were collected
Total WBC count (thousands/mm³) was measured from a whole blood sample using an ADVIA 120 automated hematology analyzer
次要结局
未报告次要终点
研究者
Mona Mohamed Abdelkhalek
assistance professor
Badr University