NCT05685524招募中不适用
Development of Diagnostic Model for Multi-cancer Diagnosis Based on DNA Methylation Biomarkers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Sensitivity
研究概览
简要总结
We intend to establish an efficient method for plasma cfDNA extraction and Bisulfite transformation to facilitate the detection of DNA methylation status using multiplex fluorescence PCR. Meanwhile, we expect to identify several plasma methylation markers that can be highly sensitive for multi-cancer detection. Finally, we will provide a pan-cancer blood test that is easy to operate, low cost, accurate and easy to promote.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(1)age >= 18 years. (2) with high suspicion of cancer diagnosed by endoscopy, other imaging examinations, pathological examinations, etc.
- •(3) no treatment with radiotherapy or chemotherapy.
排除标准
- •(1) received antineoplastic treatment such as radiation/chemotherapy. (2) not preserved as required. (3) contaminated or volume is insufficient. (4) unclear pathological results (5) incomplete patient information.
结局指标
主要结局
Sensitivity
时间窗: immediately after the procedure
The reference standard is the results of histopathological tests
Specificity
时间窗: immediately after the procedure
次要结局
未报告次要终点
研究者
研究点 (1)
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