Acute melatonin ingestion reduced muscle damage, inflammation and oxidative stress after an exhaustive exercise in obese patients.

Inflammatory responses, muscle damage and biomarkers of oxidative stress have been assessed before and after HIIE. MLT ingestion attenuated the increase of inflammation in Leucocytes (-6.63%; p<0.01), Neutrophils (-8.14%; p<0.01), and C-reactive protein (-9.1%; p<0.001)), hepatic and muscle damage in ASAT (-3.52%; p<0.001), ALAT (-3.47%; p<0.001) and Creatine kinase (-3.94%; p<0.05) and the lipid and protein peroxidation (malondialdehyde (-11.01%; p<0.05), AOPP (-16.86%; p<0.001)). Additionally, the enzymatic antioxidant biomarkers were enhanced (Thiol (+23.81%; p<0.01), Catalase (+20.17%; p<0.01)) in the MLT session compared to the placebo session after HIIE.