Pilot Study of the Best Transfer Strategy in an Oocyte Donation Programme: an Intention to Treat Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 134
- 试验地点
- 2
- 主要终点
- Cumulative live birth rate
研究概览
简要总结
It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3). Without this activation, the embryo can not continue its development. Therefore, it has been suggested that extended culture to blastocyst stage could be an option to identify and better select embryos that have been able to carry out this activation. The purpose of this study is to compare cumulative pregnancy and live birth rates following transfer of cleavage embryos or blastocysts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients under their first or second cycle of a synchronous (fresh) oocyte donation cycle.
排除标准
- •Preimplantation genetic screening or diagnosis cycles.
- •Patients with strict blastocyst-stage embryo transfer indication by the couple's treating physician.
结局指标
主要结局
Cumulative live birth rate
时间窗: at 12 months after a embryo transfer (time considered enough in order to do a minimum of one frozen-thawed cycle if pregnancy is not achieved with the fresh cycle
Total number of births considering fresh and frozen thawed embryos transferred
次要结局
- Cumulative pregnancy rate(at 12 months after a embryo transfer (time considered enough in order to do a minimum of one frozen-thawed cycle if pregnancy is not achieved with the fresh cycle)
研究者
Elisabet Clua Obrado
Head of Gamete and Embryo Donation
Institut Universitari Dexeus