NCT00002438已完成不适用
Randomized Study Comparing Itraconazole to Placebo in the Prevention of Histoplasmosis in Patients With Human Immunodeficiency Virus Infection
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Janssen, LP
- 试验地点
- 7
研究概览
简要总结
To assess the safety and efficacy of itraconazole versus placebo for prevention of histoplasmosis in HIV-infected patients with CD4 counts < 150 cells/mm3 who reside where histoplasmosis is endemic. To assess the safety and efficacy of itraconazole for preventing other debilitating fungal infections, such as cryptococcosis, aspergillosis, recalcitrant oropharyngeal or vaginal candidiasis, and recurrent esophageal candidiasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
入排标准
- 年龄范围
- 13 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have:
- •HIV infection.
- •Residence in an area endemic for H. capsulatum.
- •Absolute CD4 count < 150 cells/mm
- •No current or past active histoplasmosis.
- •No other active fungal infection.
- •Life expectancy of at least 1 year.
排除标准
- •Co-existing Condition:
- •Patients with the following symptoms or conditions are excluded:
- •Life-threatening infection or malignancy other than cutaneous Kaposi's sarcoma.
- •Inability to take oral medication.
- •Concurrent Medication:
- •Systemically-active antifungals.
- •Investigational drugs (expanded access drugs are acceptable).
- •Rifampin.
- •Rifabutin.
- •Terfenadine.
- •Astemizole.
- •Phenobarbital.
- •Phenytoin.
- •Carbamazepine.
- •H2 blockers.
- •Omeprazole.
- •Continual antacids.
- •Patients with the following prior conditions are excluded:
- •History of intolerance to imidazole or azole compounds.
- •Prior Medication:
- •Excluded within 1 month prior to study entry:
- •Investigational drugs (expanded access drugs are acceptable).
- •Excluded within 15 days prior to study entry:
- •Rifampin.
- •Rifabutin.
- •Terfenadine.
- •Astemizole.
- •Phenobarbital.
- •Phenytoin.
- •Carbamazepine.
研究者
研究点 (7)
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