Synergistic Effects of Anxiety and Alcohol Use Among Latinos and Its Sociocultural Mechanisms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 2
- 主要终点
- State-Trait Anxiety Inventory, State Version (STAI-S)
研究概览
简要总结
The purpose of this study is to examine the pharmacological effects of alcohol on acute anxiety levels in a sample of Latino drinkers, and cultural experiences influencing these relationships.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •21-65 years of age
- •moderate or heavy drinker based on a past-month AUDIT score >= 8.
排除标准
- •Possibility of being pregnant (verified by urine sample);
- •Self-reported history of or treatment for alcohol/other drug problems (as required by the IRB in past human alcohol administration research);
- •Moderate risk for drug problems as indicated by SMAST scores ≥ 5 or ASSIST scores of ≥ 4 (see Measures);
- •Medical conditions that contraindicate the use of alcohol (e.g., diabetes, liver disease);
- •Current use of psychiatric meds or any meds with alcohol contraindication (e.g., antibiotics);
- •Current non-alcohol substance use disorder;
- •Active suicidality (i.e., suicidal ideation, intent, and/or plan) or current psychosis.
结局指标
主要结局
State-Trait Anxiety Inventory, State Version (STAI-S)
时间窗: 5 minutes before alcohol administration, and 5 minutes after alcohol administration.
The State-Trait Anxiety Inventory, State Version (STAI-S) is a 20-item self-report questionnaire which assesses state (i.e., current) anxiety. Participants are asked to rate the frequency with which they experience a variety of anxiety symptoms (e.g., "I feel nervous and restless") on a 4-point scale (1 = almost never to 4 = almost always). Total scores (range = 20-80) are computed by summing individual item scores; higher scores indicate higher state anxiety. The State-Trait Anxiety Inventory, State Version (STAI-S) will be used to measure manifest anxiety among participants 5 minutes before, and 5 minutes after, the alcohol administration. We will specifically measure changes in manifest anxiety from pre- to post-alcohol administration by subtracting the participant's score on the STAI-S after the alcohol administration from the participant's score on the STAI-S before the alcohol administration.
Alcohol Urge Questionnaire (AUQ)
时间窗: 5 minutes before alcohol administration, and 5 minutes after alcohol administration.
Urge to drink will be measured using the internally consistent, reliable, and well-validated Alcohol Urge Questionnaire (AUQ), an 8-item measure of state (current) urge to drink alcohol. Items are rated on a 7-point scale from 1 = "strongly disagree" to 7 = "strongly agree." A total score is computed by adding responses to each of the items. Higher scores indicate a stronger urge to drink. The Alcohol Urge Questionnaire (AUQ) will be used to measure urge to drink among participants at 5 minutes before, and 5 minutes after, the alcohol administration. We will specifically measure changes in urge to drink from pre- to post-alcohol administration by subtracting the participant's score on the AUQ post-alcohol administration from the participant's score on the AUQ pre-alcohol administration.
Amount of alcohol consumed in "standard drinks" (0.6 oz. ethanol equivalents, 12 oz. U.S. domestic beer, 5 oz. 12% alcohol table wine, 1.5 oz. 80-proof hard liquor)
时间窗: 5 minutes after participating in the stressor task.
Amount of alcohol consumed in "standard drinks" (0.6 oz. ethanol equivalents, 12 oz. U.S. domestic beer, 5 oz. 12% alcohol table wine, 1.5 oz. 80-proof hard liquor) will be estimated for each participant.
次要结局
- Kulis, Marsiglia & Nieri's (2009) Substance Use Attitudes/Expectancies Scale(5 minutes before alcohol administration.)
研究者
Andres G. Viana
Assistant Professor
University of Houston