Improving the Therapeutic Ratio by Using Proton Beam Radiation Therapy for Patients With Stage IA-IIIBX (Bulky/Non-bulky) Hodgkin Lymphoma Involving the Mediastinum Following Standard Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.
研究概览
简要总结
The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.
详细描述
3 treatment plans will be created to deliver between a total of 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV).
- Proton Plan
- Conventional Plan
- Intensity Modulated Radiotherapy (IMRT) Plan
The patient will then receive the radiation modality with the lowest percentage of the body receiving 4 Gy (V4Gy/CGE)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed "classic" Hodgkin lymphoma.
- •Completed chemotherapy.
排除标准
- •Prior radiotherapy.
- •Prior or concurrent cancer other than non-melanomatous skin cancer.
研究组 & 干预措施
Proton Radiation Plan
干预措施: Proton Radiation Plan (Radiation)
Conventional Photon Radiation Plan
干预措施: Conventional Photon Radiation Plan (Radiation)
Intensity Modulated Radiation Plan
干预措施: Intensity Modulated Radiation Plan (Radiation)
结局指标
主要结局
Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.
时间窗: Immediately proceeding completion of each of the three treatment plans
次要结局
- Percentage of Participants Who Survived(4 years after beginning of radiation therapy)
- Percentage of Participants Who Did Not Have Disease Progression(4 years after beginning of radiation therapy)