Comparison of Different Types of Postoperative Pulmonary Recruitment and Predicting Its Efficacy Following Off-pump Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 2
- 主要终点
- Respiratory support
研究概览
简要总结
The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism. The investigators compare three different types of alveolar recruitment in patient after cardiac surgery, to reveal which one is better.
详细描述
The study compares three different approaches to alveolar recruitment maneuvers in the immediate postoperative period after off-pump coronary bypass grafting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 75
- •Off-pump coronary artery bypass grafting
- •Possibility to discontinue respiratory support in the first day after intervention
排除标准
- •Signs of ARDS
- •COPD in decompensation phase
- •Requirement for inotropic support(epinephrine >0,1 mcg/kg/hr)
- •Bronchiectases
- •Pregnancy
- •Morbid obesity
- •Aortic aneurism
- •AMI in previous month
研究组 & 干预措施
Recruitment 40x40
The group where recruitment is performed by increase in airway pressure up to 40 cm H2O for 40 seconds
干预措施: Alveolar recruitment (Procedure)
Recruitment PEAK40
Increase in peak airway pressure up to 40 cm H2O during tidal ventilation
干预措施: Alveolar recruitment (Procedure)
Recruitment 15x300
Recruitment by increase in airway PEEP up to 15 cm H2O for 300 sec
干预措施: Alveolar recruitment (Procedure)
No recruitment
No recruitment is performed: standard respiratory support.
干预措施: Alveolar recruitment (Procedure)
结局指标
主要结局
Respiratory support
时间窗: 24 hrs
The duration of the postoperative respiratory support
次要结局
- The incidence of postoperative atelectasis(24 hrs)
- Incidence of reintubation(24 Hrs)
- Oxygenation(12 hrs after extubation)
- Length of ICU and hospital stay(28 Days)
研究者
Vsevolod V. Kuzkov
Associate Professor, MD, PhD
Northern State Medical University