TGFB1 and LAMA1 Gene Polymorphisms in Turkish Children With High Myopia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 151
- 主要终点
- Genetic basis of high myopia
研究概览
简要总结
The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.
Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Screening
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 3 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients under the age of 13
- •Patients with cycloplegic refraction values ≥6 D (for study group)
- •Emmetropic patients (for control group)
排除标准
- •Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease)
- •Patients with history of ocular surgery
研究组 & 干预措施
Study group
Children with cycloplegia refractive error more than -6 D TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined
干预措施: TGFB1 AND LAMA1 GENE POLYMORPHISMS (Genetic)
Control group
Emmetropic children TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined
干预措施: TGFB1 AND LAMA1 GENE POLYMORPHISMS (Genetic)
结局指标
主要结局
Genetic basis of high myopia
时间窗: 4 years
evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia
次要结局
未报告次要终点
研究者
Elif Demirkilinc Biler
Co-investigator
Ege University