Association Between Household Health Behaviors and Asthma in Children
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Pulmonary function test (FEV1/FVC ratio)
研究概览
简要总结
This study plan to study the association between household health behavior (cleaning habits) and children's asthma. In addition, reconfirm the health effects of indoor environmental exposure to phthalates plasticizers, mite, fungi, and bacteria, and cockroaches on children's asthma. Thus, the investigators can provide a non-pharmacological intervention to reduce the disease burden of children's asthma and allergic diseases.
详细描述
The investigators plan to invite 80 children, aged 7-12 years-old who have physician-diagnosed asthma, and another age- and gender-matched children without asthma to join our study. First, obtaining clinical data of disease status, and ask participants to fill out questionnaires after recruiting. Second, participants have to record body temperature, peak expiratory flow, heart rate, finger O2 saturation percentage, asthma attack frequency continuously by care-giver every day. Third, the investigators will perform indoor environmental assessments in the subject's house, including indoor air quality, dust samples, culture for fungi and bacteria, and cockroaches. The investigators will also count the dust mites and measure phthalates concentration in every dust sample.
Then, health behavior intervention for one month will be provided to every participant. The investigators will teach children's guardians (care-giver) how to change the health behaviors to clean indoor environment, including the health behaviors in bedroom, kitchen room, restroom, refrigerator, washing machine, and incense burning hall. After 1 months, the investigators will investigate whether changing health behavior affects the exposure of phthalates, dust mites, fungi, bacteria, and cockroaches, and evaluate the effects of health behavior intervention on the clinical status of children's asthma. Children's asthma severity assessment will be recorded by ACT and also by symptomatology every day. Household health behaviors (cleaning habits) questionnaires also will be completed per week and continuously for 4 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 7-12 years-old who have physician-diagnosed asthma
- •stable patient
排除标准
- •acute allergies
- •severe brain and heart disease
- •mental illness
结局指标
主要结局
Pulmonary function test (FEV1/FVC ratio)
时间窗: one month
Before and after the intervention, test for the FEV1/FVC ratio in the hospital as an indicator of asthma status.
phthalates concentrations
时间窗: one month
Sampling in a fixed area in the subject's bedroom, and phthalates concentration will be analyzed in the laboratory.
Peak expiratory flow changes
时间窗: one month
Using peak flow meter to monitor the participant's peak expiratory flow values in the morning and evening to effectively evaluate subject's asthma status.
fractional concentration of exhaled nitric oxide
时间窗: one month
Before and after the intervention, test for the levels of fractional exhaled nitric oxide in the hospital to evaluate the condition of airway inflammation.
Pulmonary function test (FVC)
时间窗: one month
Before and after the intervention, test for the volumes of the forced vital capacity (FVC) in the hospital as an indicator of asthma status.
Symptomatology (wheezing)
时间窗: one month
Asthma symptom is recorded daily by caregivers.
Symptomatology (chest tightness)
时间窗: one month
Asthma symptom is recorded daily by caregivers.
dust mites allergen concentrations
时间窗: one month
Before and after the intervention, allergen concentrations will be sampled in a fixed area in the subject's bedroom, and dust mites' antibody will be analyzed in the laboratory.
Pulmonary function test (FEV1)
时间窗: one month
Before and after the intervention, test for the volumes of the forced expiratory volume in one second (FEV1) in the hospital as an indicator of asthma status.
Symptomatology (cough)
时间窗: one month
Asthma symptom is recorded daily by caregivers.
cockroach numbers
时间窗: one month
Before and after the intervention, count the numbers of cockroach will be sampled for every week, in a fixed area in the subject's bedroom.
次要结局
未报告次要终点