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临床试验/NCT04639856
NCT04639856已完成不适用

ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting

Armed Forces Institute of Cardiology, Pakistan2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2018年7月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
60
试验地点
2
主要终点
ICU Stay

研究概览

简要总结

Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure. In about 80% of the cases worldwide, it is currently performed with cardiopulmonary bypass (CPB) with cardiac arrest. Cardiopulmonary bypass leads to a systemic inflammatory response, which may be induced by the contact of circulating blood with artificial surfaces of the extracorporeal circuit.[1] To reduce postoperative complications caused by systemic inflammation, off-pump CABG was reintroduced into clinical practice in the early 1990s. During off-pump surgery, the coronary artery grafts are placed on coronaries of a beating heart, thereby avoiding aortic cross clamping and CPB. [1] There are many studies and debates about the two approaches to cardiac revascularization via CABG. This study aims to answer the question as to difference in the ICU stay of patients with low ejection fraction undergoing cardiac revascularization bet ween off pump and on pump coronary artery bypass grafting and better treatment option shall be adopted in future.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
40 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All patients of either gender between the ages of 40 to 80
  • Ejection fraction of less than or equal to 35% undergoing CABG.
  • undergoing CABG.

排除标准

  • Patients with ejection fraction of more than 35%
  • Patients with previous history of cardiac revascularization
  • Patients with previous history of chronic kidney disease and obstructive sleep apnea.

结局指标

主要结局

ICU Stay

时间窗: 6 Months

post operative ICU stay in patients undergoing cardiac revascularization

次要结局

未报告次要终点

研究者

发起方
Armed Forces Institute of Cardiology, Pakistan
申办方类型
Other
责任方
Principal Investigator
主要研究者

Muhammad Bilal

Cardiac Surgeon

Armed Forces Institute of Cardiology, Pakistan

研究点 (2)

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