NCT02312284已完成不适用
Observational Study on the Patients With Rectal Cancer: Experience From Cancer Hospital, Chinese Academy of Medical Sciences 2000-2010
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3,995
- 试验地点
- 1
- 主要终点
- Locoregional recurrence free survival
研究概览
简要总结
The aim of this observational study is to retrospectively collect current survival data for 3995 primary rectal cancer patients who were extracted from 5097 rectal cancer patients admitted in Cancer Hospital, Chinese Academy of Medical Sciences from January 2000 to December 2010. Moreover, based on a Cox model, we want to develope a nomogram that predicts local recurrence, distant metastases, and survival for patients with rectal cancer treated with pre- or postoperative chemoradiotherapy (CRT).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged older than 18 years
- •American Joint Committee on Cancer (six edition) stage I through IV disease
- •Received either transabdominal resection, transanal excision, preoperative radiotherapy or chemoradiotherapy
- •Had the histologic subtypes adenocarcinoma (not otherwise specified, mucinous or mucin-producing, mixed cell or with mixed subtypes, tubular, and papillary)
排除标准
- •Had the histologic subtypes squamous cell carcinoma, carcinoid, neuroendocrine tumor, small cell carcinoma, leiomyosarcoma, sarcoma, gastrointestinal stromal sarcoma, melanoma, carcinosarcoma, rhabdoid tumors, or malignant peripheral nerve sheet tumors
- •Only receive palliative surgery such as colostomy, sigmoidostomy
- •Received palliative radiotherapy or chemoradiotherapy for metastatic disease
- •With unresectable distant metastasis in liver, lung, bone, central nervous system , or peritoneal transplantation
- •Had no detailed medical records
结局指标
主要结局
Locoregional recurrence free survival
时间窗: 5-10 years
Distant metastasis free survival
时间窗: 5-10 years
Overall survival
时间窗: 5-10 years
Cancer-specific survival
时间窗: 5-10 years
次要结局
- Surgery complication(within 30 days after surgery)
- Chemotherapy/Radiotherapy/Chemoradiotherapy toxicities(the duration of hospital stay (an expected average of 6 weeks for chemoradiotherapy and 4-6 months for chemotherapy), as well as within 30 days after completion of the treatment and all the follow-up time)
研究者
Jing Jin, M.D.
MD
Chinese Academy of Medical Sciences
研究点 (1)
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