Role of IL 12 and IL 23 as Potential Biomarkers in Diagnosis of Early Crohn's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Sensitivity of IL-23 to predict Crohn's disease
研究概览
简要总结
This study aims to evaluate the role of Interleukin (IL)-12 and IL-23 as potential biomarkers in the diagnosis of early Crohn's disease.
详细描述
Crohn's disease (CD) is characterized by periods of remission and relapse, with symptoms ranging from abdominal pain and diarrhea to severe complications such as fistulas and intestinal obstruction.
Interleukins (ILs) are known clusters of cytokines that regulate the proliferation, development, and activation of immune cells. IL-12 is predominantly a pro-inflammatory cytokine secreted by antigen-presenting cells (APC) in response to sensing of microbial components by Toll-like receptors. Another member of this family, IL-23 is also produced by DCs and macrophages after toll-like receptors (TLRs) engagement.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 65 years.
- •Both sexes.
- •Patients who are suspected of having Crohn's disease clinically and by colonoscopy (like ulcers, fistulas, or skip lesions).
- •Non-specific ileitis by histopathology.
排除标准
- •Patients with no pathological samples through colonoscopy.
- •History of other significant gastrointestinal diseases (e.g., colon cancer, ischemic bowel disease).
- •Immunosuppressive therapy or biologic agents at the time of study.
- •Previous abdominal surgeries.
结局指标
主要结局
Sensitivity of IL-23 to predict Crohn's disease
时间窗: 6 months after procedure
Sensitivity of IL-23 to predict Crohn's disease will be recorded.
次要结局
- Sensitivity of IL-12 to predict Crohn's disease(6 months after procedure)
研究者
Mohamed Galal Flefel
Lecturer of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University