Ropivacaine Versus Ropivacaine with Lidocaine Mixture in Poplitial-Sciatic Nerve Block for Below Knee Surgeries- a Randomized, Single Center Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 110
- 主要终点
- Time to complete sensory block
研究概览
简要总结
Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years old)
- •Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
- •Capable of providing informed consent
排除标准
- •History of allergic reaction to local anesthetics
- •Pre-existing neurological disorders affecting lower limbs
- •Significant renal or hepatic impairment
- •Pregnancy or breastfeeding
- •Less than 60kg
- •Inability to provide informed consent
研究组 & 干预措施
Ropivacaine
Popliteal block using Ropivacaine 100 mg in 20 mL
干预措施: Ropivacaine 0,5% (Drug)
Ropivacaine anmd Lidocaine
Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL
干预措施: Ropivacaine and Lidocaine (Drug)
结局指标
主要结局
Time to complete sensory block
时间窗: Tested every 2 min up to 60 min
The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.
次要结局
- Duration of analgesia(up to 48 hours after discharge)
- Pain score at 6 hour post-block(6 hours after nerve block)
- Patient satisfaction(at 48 hour)
研究者
Cheng Lin
Anesthesiologist
Lawson Health Research Institute
