To study the effectiveness of Angustura vera in Knee Osteoarthritis using Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index: Single arm, interventional study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 41
- 试验地点
- 1
研究概览
简要总结
Knee osteoarthritis (ICD-11: FA01.0) is the most common form of Osteoarthritis worldwide and is associated with significant morbidity, disability, and reduced quality of life, particularly among the ageing population. Angustura vera (Galipea officinalis), prepared from the bark of a tree of the Rutaceae family native to Colombia and Venezuela, is a lesser-used homoeopathic medicine. It was first proved by Samuel Hahnemann and later described by Timothy Field Allen in the Materia Medica. Homoeopathic literature mentions its action on joints and bones, particularly in knee Osteoarthritis, with symptoms such as joint pain, stiffness after rest, and difficulty in walking. However, due to limited clinical studies with small sample sizes, clear evidence regarding its effectiveness is lacking.The present study aims to evaluate the effectiveness of Angustura vera in patients with knee Osteoarthritis. The objective of the study is to compare the changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at baseline and after 4 months of treatment with Angustura vera in patients with knee Osteoarthritis.The results of this study are expected to support wider and more confident use of this medicine by homoeopathic practitioners in their routine clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Cases of primary knee osteoarthritis.
- •Patients diagnosed under ACR Diagnostic Guidelines for Osteoarthritis of knee.
- •Radiologically confirmed cases of knee Osteoarthritis (Kellgren–Lawrence Grade I–III).
- •Patients who have already had other method of treatment but now intend to undergo homoeopathic treatment, after providing a gap of two weeks as wash-out period.
- •Baseline WOMAC score indicating mild (25-41) to moderate symptoms (42-69).
排除标准
- •Pregnant and lactating women.
- •Patients with Psychiatric disorders and drug addiction.
- •Presence of unstable or serious medical illnesses such as uncontrolled diabetes, thyroid disease, cardiovascular disease, hepatic or renal failure, neurological disorders that may interfere with treatment or assessment.
- •Patients who continue to be under other method of treatment.
- •Patients not willing to undergo any investigation, if so advised.
- •Patient who may discontinue their treatment.
- •Patient who are intermittently taking other method of treatment during the homoeopathic treatment.
研究者
Dr Aarti Sharma
National Institute of Homoeopathy