NCT00004229已完成1 期
A Phase I Surrogate Endpoint Trial of Human Recombinant Endostatin in Patients With Advanced Solid Tumors Amenable to Biopsy
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
研究概览
简要总结
Phase I trial to study the effectiveness of endostatin in treating patients who have advanced solid tumors. Endostatin may stop the growth of cancer by stopping blood flow to the tumor.
详细描述
OBJECTIVES:
I. Determine the optimal biologic dose of endostatin in patients with advanced solid tumors.
II. Determine the safety and tolerability of this regimen in these patients. III. Determine the extent, frequency, and duration of tumor response in these patients on this regimen.
IV. Determine the pharmacokinetic profile and interpatient pharmacologic variability of this regimen in these patients.
V. Determine the recommended phase II dose and schedule of this regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究者
研究点 (2)
Loading locations...
相似试验
Unknown
2 期
Recombinant Human Angioendostatin /PD-1 Mab Combined With First-line Chemotherapy in the Treatment of Driver Gene Negative Advanced NSCLCNon Small Cell Lung CancerEndostatinNCT05448781Affiliated Cancer Hospital & Institute of Guangzhou Medical University38
已完成
2 期
Endostar Combined With Paclitaxel and Nedaplatin in Treating Patients With Recurrent or Metastatic Esophageal CancerEsophageal Squamous Cell CarcinomaNCT02350517Yuhong Li52
Unknown
2 期
Endostar Combined With AI Regimen Compared With AI in Adjuvant TreatmentOther Disorders of Soft TissuesNCT04699214Yong Chen210
Unknown
1 期
Recombinant Human Endostatin in Combination With mFOLFOX6 in Patients With Metastatic Colorectal CancerColorectal NeoplasmNCT01310478Fudan University15
尚未招募
2 期
Recombinant Human Endostatin Combined With Envafolimab and Synchronal RadiochemotherapyLocally Advanced Squamous Non-small Cell Lung CancerNCT06279754The First Affiliated Hospital of Xinxiang Medical College30