Brain Assessment and Investigation in Heart Failure Trial - B-HeFT

Department of Cardiovascular Medicine0 个研究点目标入组 80 人开始时间: 2012年7月31日最近更新: 2023年11月20日

试验速览

Reduction in hippocampus blood flow is associated with depressive symptoms and cognitive impairment in chronic heart failure patients.

•(1) Contraindication of MRI: Cardiac devices or claustrophobia. (2) Unstable cardiac function: Patients who had uncontrolled heart failure or required intravenous inotropes. Patients receiving stent implantation for acute myocardial infarction within 3 months. (3) Past history significantly affecting cerebral blood flow and/or brain structure: MMSE < 24, mental retardation, neurodegenerative disease, psychiatric disorder, epilepsy, symptomatic stroke, symptomatic carotid stenosis with or without stenting or endarterectomy, head trauma, hydrocephalus, intracranial mass, alcohol/drug addiction, hypo/hyperthyroidism, aortic stenosis proximal to left cervical artery and/or severe aortic valve stenosis. (4) Difficulty in evaluating brain and/or cardiac MRI: Artifacts of movements or other causes. Patients with complex congenital heart diseases.

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