Short-term Effects of Humidification Devices on Respiratory Pattern and Work of Breathing During Invasive Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Change in muscle pressure-time product (PTPoes)
研究概览
简要总结
This study compares the short-term effects of a new humidification system (Hygrovent Gold) and two other humidification devices (heated and moisture exchanger and heated humidifier) on respiratory pattern and work of breathing, during invasive ventilation.
详细描述
Three humidifying devices are commonly and indifferently used during mechanical ventilation, but their impact on respiratory mechanics and, eventually, mechanical ventilation efficacy, particularly in patients highly dependent from mechanical ventilation, are not superimposable.
It has already been described that heated and moisture exchangers (HME), increasing dead space, can negatively affect ventilatory function and gas exchange, in comparison to heated humidifiers (HH).
The Hygrovent Gold, mainly because of its position between the tracheostomy and the Y-piece of the ventilatory circuit and its structure, may lead to analogous or even worse effects, determining and increase in inspiratory resistances and dead space and consequently an increase in the work of breathing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic hypercapnic respiratory failure (PaCO2 of 45 mmHg or more)
- •Long-term mechanical ventilation via tracheostomy
- •Clinical stability
排除标准
- •Non collaborative subjects
- •Acute respiratory failure
- •Haemodynamic instability
- •Encephalopathy
结局指标
主要结局
Change in muscle pressure-time product (PTPoes)
时间窗: Baseline and 60 minutes
次要结局
未报告次要终点
研究者
Annia Schreiber
MD
Fondazione Salvatore Maugeri