NCT07131878尚未招募不适用
Assesment of Treatment Outcomes of Aquired Aplastic Anemia in Children : A Retrospective and Prospective Cohort
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 35
- 主要终点
- To evaluate the treatment outcomes of children diagnosed with aplastic anemia.
研究概览
简要总结
The goal of this observational study is to to assess of treatment Outcomes of Aquired Aplastic Anemia in children
详细描述
This study will be conducted to investigate the clinical outcomes, and treatment modalities of patients diagnosed with aquired aplastic anaemia at Assiut University children Hospital
The main question it aims to answer is:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children aged 1-18 years diagnosed with acquired aplastic anemia, as confirmed by bone marrow examination and fulfilling diagnostic criteria (e.g., bone marrow cellularity <25% and at least two of the following: absolute neutrophil count <500/μL, platelet count <20,000/μL, absolute reticulocyte count <60,000/μL)
- •The bone marrow biopsy should be compitable with diagnosis
- •Diagnosed and/or treated at Assiut University Children's Hospital between Agust 2023 and Augst
- •Patients with complete medical records, including diagnostic, laboratory, and treatment data
排除标准
- •Patients with inherited bone marrow failure syndromes (e.g., Fanconi anemia, dyskeratosis congenita) as confirmed by genetic testing or family history
- •Patients with incomplete or missing essential data in their medical records.
- •Patients diagnosed outside the specified study period or managed primarily at other institutions.
- •Patinets with neoplastic or granulomatous disease involving the bone marrow, systemic lupus erythematosus, AIDS, hypersplenism or other conditions associated with pancytopenia such as myelodysplastic syndrome,and paroxysmal nocturnal hemoglobinuria.
- •Patients exposed to antineoplastic chemotherapy or radiotherapy were excluded
结局指标
主要结局
To evaluate the treatment outcomes of children diagnosed with aplastic anemia.
时间窗: July 2023-July 2026
次要结局
- To assess response rates to various treatment modalities, including: oImmunosuppressive therapy (IST) oHematopoietic stem cell transplantation (HSCT) oSupportive care only(July 2023_July 2026)
研究者
Marwa Mohamed Abozaid
Resident doctor
Assiut University
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