A Study of the Effect of Combination Lumacaftor and Ivacaftor on Glucose Tolerance in Persons With Cystic Fibrosis Who Are Homozygous for the Phe508del Cystic Fibrosis Transmembrane Conductance Regulator Mutation.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Change in Fasting Glucose
研究概览
简要总结
The purpose of this research study is to find out if the combined therapy lumacaftor-ivacaftor effects how people with cystic fibrosis respond to an oral glucose tolerance test, a test for diabetes.
详细描述
This is a single center, open label study with crossover in patients with Cystic Fibrosis (CF). Patients will have 2-3 visits at the Diabetes Center at Massachusetts General Hospital (MGH).
The participants will have been previously screened clinically to make sure they are candidates for starting the combination drug, lumacaftor-ivacaftor. These patients will be contacted prior to their first visit to discuss enrollment in the study.
At the first study visit (Visit 1), the participant will come to the Diabetes Center after an overnight fast of at least 8 hours. The following will occur at this study visit: informed consent; brief medical history; weight and height; vital signs and blood pressure; blood draw for DNA extraction, and an extra research tube for storage; administration of 75g Glucola load as per a standard oral glucose tolerance test (OGTT) protocol; and blood work for glucose and insulin at 30, 60, 90 and 120 minutes after the glucose load. This will be scheduled at a time that is convenient to the patient, with an attempt to coordinate with the patient's visit to the CF clinic prior to starting lumacaftor-ivacaftor combination drug.
At the 2nd study visit (Visit 2), which will take place 3 months after starting the combination drug, the participant will again come to the Diabetes Center after an overnight fast of at least 8 hours. The participant will undergo a second OGTT as in the first visit. The 3rd study visit (Visit 3) will be 6 months after initiation of the drug, and will have a repeat administration of an OGTT. If a participant starts the combination drug before enrolling in the study, he/she can still participate in the study as long as he or she has had a clinical OGTT performed within 6 months of starting the combination drug. In these cases, the informed consent, brief medical history, weight and height and vital signs and blood pressure, as well as blood draw for DNA will occur on the Visit 2, which will be the first study visit for these participants. If a clinical OGTT had been performed prior to but within 6 months of starting the combination therapy, this OGTT can be used in analysis of the data, although will not have the full amount of data as the study OGTT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years old or greater
- •Patients diagnosed with CF, genotype homozygous PheDel508
- •Subject is planning on starting lumacaftor-ivacaftor for clinical reasons, with no contraindication for starting the drug* OR subject is taking combination drug and had an OGTT done at a partners facility in the 6 months prior to initiating the drug.
- •Contraindications for taking drug include abnormal liver enzyme tests, renal dysfunction, pregnancy or nursing mothers
排除标准
- •Currently taking any medications for diabetes (including oral or injectable antihyperglycemic agents and/or insulin).
- •Had an admission for CF exacerbation less than 2 weeks prior to staring the medication. This will be defined as requiring new IV or PO antibiotics different than those used in maintenance therapy.
- •Is currently taking oral glucocorticoids or has been on oral or IV glucocorticoids in the past 2 weeks.
研究组 & 干预措施
Lumacaftor Ivacaftor
Subjects will get an OGTT before and after starting the combination therapy lumacaftor-ivacaftor.
干预措施: Lumacaftor-ivacaftor (Drug)
Lumacaftor Ivacaftor
Subjects will get an OGTT before and after starting the combination therapy lumacaftor-ivacaftor.
干预措施: OGTT (Other)
结局指标
主要结局
Change in Fasting Glucose
时间窗: 6 months
This will compare baseline to 6 months after starting the medication
次要结局
- Genetic risk score(6 months)
- Pulmonary function test (PFT) FEV1 measurements(6 months)
- Change in Fasting Insulin(6 months)
研究者
Jose C. Florez, MD, PhD
Chief of the Diabetes Unit, Associate Professor Harvard Medical School
Massachusetts General Hospital