ASSESSMENT OF PARENCHYMAL AND AIRWAY CHANGES ON HRCT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Morphometric and software-generated parameters like LAA and BWT can help us not only qualitatively estimate the predominant pattern of COPD in the patient but also help us quantify - percentage low attenuation areas to lung volume ratio would yield quantitative degree of parenchymal destruction by emphysematous changes of COPD at the time of study.Bronchial wall thickness would yield the affliction of airways as a marker of changes of chronic bronchitis component of COPD at the time of study.
研究概览
简要总结
BACKGROUND -
COPD is typified by the occurrence of an airway obstruction, which is non-reversible on bronchodilator administration and occurs secondarily to airway narrowing, emphysema, or a combination of both .
The majority of cases , in clinical practice have varying components of both phenotypes. The purpose of this study is to prospectively quantifying both the components in patients of COPD.
Variable degree of overlap between the two subtypes of COPD are seen in routinely.
Using thin slice helical CT if quantitative and qualitative evaluation of COPD is done it will help quantify the extent of disease , decern and distinguish among the subtypes of COPD , assess the severity of the disease and help in prognostication.
Recent advances in software presets and imaging acquisitions aid not only in qualitative charecterisation of air-way and parenchymal disease but also quantify and grade its severity . Separate 3D reconstruction of airway and parenchymal components from raw 1 mm sections with automated detection of airways and emphysematous areas help quantify the degree of airways and parenchymal affliction in COPD.
AIM -
The purpose of this study is to confirm and characterize COPD into its subtypes and quantify it’s severity using MDCT.
OBJECTIVES -
•1. To assess the percentage of Low attenuation areas in the lung parenchyma to quantify emphysematous changes in the lung.
•2. To assess the bronchial wall thickness of segmental and sub-segmental airways to detect and grade chronic bronchitis.
KNOWLEDGE GAP -
Spiro-metric analysis of the disease as per GOLD criteria fails to reflect – 1. Subtype predominance 2. Degree of airway and parenchymal affliction
Using thin slice helical CT if quantitative and qualitative evaluation of COPD is done it will help quantify the extent of disease , decern and distinguish among the subtypes of COPD , assess the severity of the disease and help in prognostication.
JUSTIFICATION OF THE STUDY -
•COPD is a disease with significant morbidity and mortality .
•Variable degree of overlap between the two subtypes of COPD are seen in routinely.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 35.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Clinical suspicion of COPD.
- •Spirometric abnormalities satisfying the GOLD criteria Age >35 yrs.
排除标准
- •Previous surgical intervention on the lung .
- •Partial lung – post lobectomy/ pneumectomy / congenital disorders.
- •Lung tumors.
- •Severe lung disease other than COPD ( Pneumonia , Pleural effusion , Pulmonary edema).
- •Metal grafts , endobronchial tubes , pacemakers.
结局指标
主要结局
Morphometric and software-generated parameters like LAA and BWT can help us not only qualitatively estimate the predominant pattern of COPD in the patient but also help us quantify - percentage low attenuation areas to lung volume ratio would yield quantitative degree of parenchymal destruction by emphysematous changes of COPD at the time of study.Bronchial wall thickness would yield the affliction of airways as a marker of changes of chronic bronchitis component of COPD at the time of study.
时间窗: To be assessed at the end of study.
次要结局
- Qualitative estimation of the predominant pattern of COPD ( emphysematous vs Chronic Bronchitis ) in the study population , and help us sub-classify the predominant pattern of emphysematous changes.(Percentage expression of the predominant pattern of the COPD.)