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临床试验/NCT05859048
NCT05859048招募中不适用

Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians

Cardiology Research UBC6 个研究点 分布在 1 个国家目标入组 1,360 人开始时间: 2024年3月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
1,360
试验地点
6
主要终点
Number of HF hospitalizations

研究概览

简要总结

The goal of this study is improve the screening of heart failure and identify patients early who are at risk of heart failure.

The main question[s] it aims to answer are:

• will an electronic health records (EHR) case finding algorithm for heart failure, followed by N-Terminal pro-brain natriuretic peptide (NT-proBNP) screening and artificial intelligence (AI) echocardiogram compared to usual care identify patients at risk for heart failure earlier than standard of care?

Participants will be enrolled and randomized to either standard of care (SOC) or intervention arm:

SOC arm: electronic health records will be reviewed over six months for assessments performed to identify heart failure.

Intervention arm: blood sample for N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) at local laboratory . For elevated NT-proBNP results (>125pg/ml) an artificial intelligence (AI) echocardiogram and 12 lead electrocardiogram (ECG) will be performed at study site (within 28 days of NT-proBNP result). EHR will be reviewed at six months

详细描述

Heart failure describes a chronic condition where the heart muscle is no longer able to supply the body with enough oxygen and nutrients. This can lead to fatigue and poor quality of life. Often, people do not know they have heart failure until they end up in hospital. This study wants to improve the screening of heart failure and identify patients at risk for heart failure earlier. This will help determine if early-screening and treatment can help prevent further decline in these patients.

This is a randomized, un-blinded study comparing usual care to an intervention group receiving early heart failure testing. Pre-screening will be performed using extracted primary care electronic health records with the case finding algorithm based on the inclusion and exclusion criteria. An invitation letter will be send to prospective patients which include a registration telephone number and link to dedicated study website. The invitation for contact will adopt an "opt out" approach (ask the potential participant to contact the coordinating centre if they do not wish to be contacted).

Potential participants not opting out, or opting in, within 2 weeks of invitation mailing will be sent a patient information package along with follow up contact by research team.

Consented participants will be randomized either to usual care or interventions group and followed for six months. Intervention group will have NT-proBNP drawn and those with an elevated NT-proBNP (>125pg/mL) will have a study visit with assessments to include, physical examination, electrocardiogram and study AI echocardiogram.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Screening
盲法
None

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Male or female > 40 years of age
  • Informed consent
  • At least two additional risk factors for Heart Failure (HF):
  • Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis or an epicardial coronary artery (50% left main stem or >70% left anterior descending, circumflex or right coronary artery)).
  • Diabetes type 1 or
  • Persistent or permanent atrial fibrillation.
  • Previous ischemic or embolic stroke.
  • Peripheral artery disease (previous surgical or percutaneous revascularization or documented stenosis >50% of major peripheral arterial vessel.
  • Chronic kidney disease (defined as an estimated glomerular filtration rate (eGFR)<60 milliliters per minute (mL/min)/1.73m2 or eGFR 60-90 mL/min/1.73m2 and urine albumin-creatinine ration (UACR) >300mg/g).
  • Regular loop diuretic use for >30 days within 12 months prior to consent.
  • Chronic obstructive pulmonary disease (COPD) evidenced by one of the following: Pulmonary Function Test (PFT) showing airway obstruction, diagnosis of respiratory physician, CT scan reporting presence of emphysema, or treatment with national guidance advocated COPD therapy.

排除标准

  • Inability to give informed consent (e.g. due to significant cognitive impairment).
  • Previous diagnosis of heart failure. This is any diagnosis of heart failure with any ejection fraction of any cause.
  • Renal replacement therapy.
  • Anyone who, in the investigator's opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period.

研究组 & 干预措施

Routine care arm

No Intervention

Participants will be remotely monitored for number of heart failure events

Investigational arm guided by NT-proBNP result

Active Comparator

NT-proBNP drawn and if level elevated (>125 pg/ml) a study visit with artificial intelligence (AI) echocardiogram, electrocardiogram (ECG), and heart failure (HF) focused examination conducted

干预措施: NT-proBNP (Diagnostic Test)

Investigational arm guided by NT-proBNP result

Active Comparator

NT-proBNP drawn and if level elevated (>125 pg/ml) a study visit with artificial intelligence (AI) echocardiogram, electrocardiogram (ECG), and heart failure (HF) focused examination conducted

干预措施: AI echocardiogram (Diagnostic Test)

Investigational arm guided by NT-proBNP result

Active Comparator

NT-proBNP drawn and if level elevated (>125 pg/ml) a study visit with artificial intelligence (AI) echocardiogram, electrocardiogram (ECG), and heart failure (HF) focused examination conducted

干预措施: electrocardiogram (Diagnostic Test)

Investigational arm guided by NT-proBNP result

Active Comparator

NT-proBNP drawn and if level elevated (>125 pg/ml) a study visit with artificial intelligence (AI) echocardiogram, electrocardiogram (ECG), and heart failure (HF) focused examination conducted

干预措施: Cardiovascular physical examination (Other)

结局指标

主要结局

Number of HF hospitalizations

时间窗: enrollment to six months

Number of admission for HF

Number of participants diagnosed with heart failure (HF) according to the European Society of Cardiology 2021 HF guidelines

时间窗: enrollment to six months

Incidence of HF diagnosis in outpatient settings Urgent heart failure visit. Heart failure hospitalization.

Number of outpatient HF visits

时间窗: enrollment to six months

Number of outpatient visits for HF with initiation or intensification of oral HF therapy

Number of urgent HF visit

时间窗: enrollment to six months

Incidence of HF presentation in urgent care setting with administration of intravenous HF therapies

次要结局

  • HF events in HFrEF(enrollment to six months)
  • incidence of prescription for guideline recommended HF therapies in patients diagnosed with HFrEF(enrollment to six months)

研究者

发起方
Cardiology Research UBC
申办方类型
Other
责任方
Principal Investigator
主要研究者

Nathaniel Hawkins

Principal Investigator

Cardiology Research UBC

研究点 (6)

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