TCTR20191205004已完成不适用
Impact of splenectomies on hematopoietic stem cell transplantation outcomes of pediatric transfusion dependent thalassemia (TDT) patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- one
- 入组人数
- 96
研究概览
简要总结
Although splenectomies prior toHSCT for the TDT patients in our cohort were associated with faster neutrophil engraftments and lower rejection rates, they did not produce significantly better OS or affect the mortality. As the splenectomies did not provide any distinct advantages, this procedure should not be routinely performed as a pre-HSCT regimen for TDT patients with splenomegaly.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- N/A (No limit) 至 18 Years（—）
- 性别
- All
入选标准
- •Transfusion dependent thalassemia patients who underwent HLA-matched, related HSCTs at the Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand, from August 1st, 1987 to December 31st, 2014.
排除标准
- •Transfusion dependent thalassemia patients who underwent HLA-mismatched or unrelated HSCTs at the Department of Pediatrics, Faculty of Medicine Siriraj Hospital
研究者
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