Influence of Circulating Endothelial Progenitor Cells and Modifiable Vascular Risk Factors on Carotid Plaque Vulnerability
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Change in the Endothelial Progenitor Cells Count
研究概览
简要总结
Ischemic stroke is a leading cause of death and disability worldwide. Atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation, cell proliferation and ultimately to vessel stenosis. One of the main features related to plaque progression and vulnerability is inflammation. Positron emission tomography with 18-fluorodeoxyglucos (18-FDG PET) allows an accurate quantification of plaque inflammation and it has been proved its usefulness in predicting early stroke recurrences. The investigators aim to test how modifiable vascular risk factors influence plaque inflammation assessed by 18-FDG PET. In addition, investigators will assess the association of this inflammation and circulating endothelial progenitor cells
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic stroke within 7 days before inclusion
- •At least one atherosclerotic plaque in the internal carotid artery
- •>18 years old
排除标准
- •Cardioembolic strokes according to TOAST criteria
- •Poor functional outcome (Rankin >3) after stroke
结局指标
主要结局
Change in the Endothelial Progenitor Cells Count
时间窗: Baseline and at one year follow-up
Change in the Endothelial Progenitor Cells Count by flow cytometry
Change in the Standardized Uptake Value (SUV) of the internal carotid artery
时间窗: Baseline and at one year follow-up
Inflammation change of the internal carotid artery assessed by the Standardized Uptake Value (SUV) obtained with 18FDG-PET scan at one-year follow-up
Change in the Target-to-Background Ratio (TBR) of the internal carotid artery
时间窗: Baseline and at one year follow-up
Inflammation change of the internal carotid artery assessed by the Target-to-Background Ratio (TBR) obtained with 18FDG-PET scan at one-year follow-up
次要结局
未报告次要终点