The Relationship of Adiponectin With Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- For laboratory analyses, the collection of all blood samples from the study participants.
研究概览
简要总结
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes. M2 form is converted (or polarized) to M1 phenotype in various metabolic disorders such as obesity and type 2 diabetes mellitus.
详细描述
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes.
M2 form is converted (or polarized) to M1 phenotype in various metabolic disorders such as obesity and type 2 diabetes mellitus. In addition, these forms also are related to insulin resistance and inflammation in adipose tissue.
Today, there is no study that investigate the role of adiponectin an anti-inflammatory adipokine, on macrophage polarization in non-alcoholic fatty liver disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Persistently (at least 6 months) elevated aminotransferases
- •Ultrasonographic presence of bright liver without any other liver or biliary tract disease
- •Liver histology compatible with a diagnosis of NASH or SS
排除标准
- •A history of alcohol consumption >40 g/wk, as assessed by a detailed interview extended to family members
- •Morbid obesity [body mass index (BMI) ≥40 kg/m2], hypertension
- •Positive blood markers of viral, autoimmune, or celiac disease
- •Abnormal copper metabolism or thyroid function tests
- •A diagnosis of T2DM and systemic arterial hypertension
- •Total cholesterol (TC) ≥250 mg/dL, triglycerides (TG) ≥400 mg/dL, exposure to occupational hepatotoxins or drugs known to affect glucose and lipid metabolism
结局指标
主要结局
For laboratory analyses, the collection of all blood samples from the study participants.
时间窗: Collection of blood samples in one year and analyses of data in 3 months.
次要结局
未报告次要终点
研究者
Halil Genc
Gulhane School of Medicine
Gulhane School of Medicine