NCT01872533已完成1 期
Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Change in Insulin sensitivity
研究概览
简要总结
The purpose of this study is to look at how a reduction in oxygen levels (hypoxia) influences insulin sensitivity and carbohydrate metabolism. It is expected that 10 nights of exposure to moderate hypoxia (~ 15% O2, similar to conditions at an altitude of ~7500 feet) will improve glucose metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 20-45 years
- •Obese category (BMI > 30 kg/m2)
- •Healthy as assessed by a self-reported health questionnaire
- •Non-smokers
- •Weight stable over the past 3 months (<2kg fluctuation)
排除标准
- •Sleep apnea
- •Hypertension
- •History of altitude sickness
- •Individuals taking any chronic medications
- •Individuals taking any stimulants
- •Individuals taking beta-blockers
- •Individuals with chronic alcohol consumption (>3 drinks per day) or drug abuse.
- •Individuals unable to abstain from caffeinated beverage or alcohol the days of study testing
- •Individuals with history disease or history of stroke
研究组 & 干预措施
Hypoxia Exposure
Experimental
There was only one study arm: All participants slept in moderate hypoxia (see description below).
干预措施: Hypoxia Exposure (Other)
结局指标
主要结局
Change in Insulin sensitivity
时间窗: Change from baseline to 10 nights of hypoxia exposure
Glucose disposal and oxidation were measured using a two-step hyperinsulinemic euglycemic clamp and indirect calorimetry.
次要结局
- Change in oxygen tension in adipose tissue(Before and after 10 nights of hypoxia exposure)
- Change in gene and protein expression(Before and after 10 nights of hypoxia exposure)
- Glucose uptake in myotubes(Before 10 nights of hypoxia exposure)
研究者
Eric Ravussin
Principal Investigator
Pennington Biomedical Research Center
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Influence of Intermittent Hypoxia on Glycemic ControlHypoxemiaNCT06490900University of Texas at Austin18
终止
不适用
Consequences of Nocturnal and Daytime Hypoxemia in COPDChronic Obstructive Pulmonary DiseaseNCT00547456Northwell Health20
已完成
不适用
Hepatic Drug Biotransformation in Children With Obstructive Sleep ApneaSleep ApneaNCT00310323Virginia Commonwealth University69
已完成
不适用
Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCISpinal Cord InjuriesObesityInsulin ResistanceNCT02973438University of Miami6
招募中
不适用
The Effects of Intermittent Hypoxia on Acute Hypoxic InjuryAcute Mountain SicknessNCT05733338Capital Medical University100