Blood Biomarkers in Major Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 275
- 试验地点
- 2
- 主要终点
- describe a transcriptional signature of the Major Depressive Episode.
研究概览
简要总结
Depression is a leading cause of disability worldwide, affecting nearly 16% of the general population. Its physiopathology remains unclear. Based on gene-environment studies and epigenetic studies, a main hypothesis proposed that the major depressive episode (MDE) results from the convergence of multiple factors including biological factors such as multi-genic vulnerability, hormonal and immunological variations as well as environmental factors. As a consequence, mRNA could define a biological signature of the MDE.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Major depressive disorder at inclusion according to the DSM IV at the time of the inclusion,
- •Having a score on the scale of depression of Hamilton ( HDRS-17) > 19 at the time of the inclusion,
- •Taken care by a grown-up psychiatric department, that the coverage(care) is realized in ambulatory or during a hospitalization
排除标准
- •Schizophrenia
结局指标
主要结局
describe a transcriptional signature of the Major Depressive Episode.
时间窗: 6 months
The major aim of our study is to compare the expression level of selected genes between patient suffering from major depression and control subjects and within patients across the MDE evolution. We plan to describe a transcriptional signature of the MDE.
次要结局
- evaluate the role played by confounding factors as genetic polymorphisms,(6 months)