COMPARATIVE STUDY BETWEEN 1% ALENDRONATE GEL AND 1% METFORMIN GEL IN THE TREATMENT OF INFRA BONY DEFECTS IN PATIENTS WITH CHRONIC PERIODONTITIS- IN AN VIVO STUDY.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Reduction in Probing pocket depth (PPD) and, gain in relative attachment level (RAL),change in height of alveolar bone crest and bone fill.
研究概览
简要总结
To evaluate and compare clinically and radiographically, the efficacy of 1% Alendronate gel with 1% Metformin gel in the treatment of infra bony defects in patients suffering from chronic periodontitis. This is a clinical trial to evaluate and compare the difference between the reductions in probing pocket depth(PPD), gain in attachment level, change in height of alveolar bone crest and bone fill between the sites treated with 1% Alendronate gel and 1% metformin gel, that will be conducted in Terna Dental College, India. Evaluation will be done at baseline, 3 and 6 months after surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients with periodontal disease with a possible indication for flap surgery and having at least two intra bony defects, one on either side of the same arch, with interproximal probing depth (PD) of at least 5 mm or more after phase I therapy.
- •2.Patients maintaining proper oral hygiene status.
- •3.Systemically healthy patients.
- •4.Patients who give informed consent to participate in the study.
排除标准
- •1.Pregnant and lactating females.
- •2.Patients consuming tobacco in any form.
- •3.Patients who have undergone periodontal surgical therapy in the last 6 months in the same site.
- •4.Systemic disease or other conditions that could influence the periodontal status.
- •5.Allergy to bisphosphonates or history of their systemic use.
结局指标
主要结局
Reduction in Probing pocket depth (PPD) and, gain in relative attachment level (RAL),change in height of alveolar bone crest and bone fill.
时间窗: Baseline | 3 month | 6 month
次要结局
- Reduction in Probing pocket depth (PPD) and gain in relative attachment level (RAL), change in height of alveolar bone crest and bone fill between the sites treated with 1% alendronate gel or with 1% metformin gel.(Baseline)