The Development of Coronary Collateralization in Type 2 Diabetic Patients With Chronic Total Occlusion
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Cardiac function evaluated by echocardiography
研究概览
简要总结
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total occlusion (CTO) compared with non-diabetic patients with CTO. This retrospective cohort enrolls consecutive T2DM patients who had at least one lesion with coronary angiographic total occlusion.
详细描述
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion (COLLECT) study is a single center, retrospective cohort study to investigate potential factors associated with the development of coronary collateral circulation in diabetic patients. Investigators will consecutively enroll T2DM patients who had at least one lesion with coronary angiographic total occlusion. The development of coronary collateral circulation will be graded according to the Rentrop method and patients will be divided into poor CCC (grade 0 or 1) or good (grade 2 or 3) CCC groups according to their Rentrop grades. Baseline clinical and laboratory characteristics at hospital admission will be recorded to analyze potential factors associated with the development of coronary collateral circulation in T2DM patients with CTO. Later, their cardiac function will be evaluated by echocardiography at one year follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-90 years
- •Type 2 diabetes diagnosed by one of the following criteria:
- •HbA1c >/= 6.5% Fasting plasma glucose >/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT >/= 11.1 mmol/l Already receiving glucose-lowering agents.
- •At least one lesion with angiographic total occlusion
排除标准
- •eGFR<15mL/(min·1.73m2)
- •chronic heart failure with NYHA grade ≥3
- •had a history of coronary artery bypass grafting
- •had received a percutaneous coronary intervention within the prior 3 months
- •Malignant tumor or immune system disorders
- •Pulmonary heart disease
结局指标
主要结局
Cardiac function evaluated by echocardiography
时间窗: 12 months
Assessed by echocardiography
次要结局
- Cardiovascular events(up to 5 years)