Prize Contingency Management for Cocaine-Dependent Methadone Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- longest continuous period of cocaine abstinence
研究概览
简要总结
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and has 3 prize categories, (c) a contingency management condition that arranges a 31% probability of winning and has 3 prize categories, (d) a contingency management condition that arranges a 100% probability of winning and has 7 prize categories, (e) a contingency management condition that arranges a 31% probability of winning and has 7 prize categories, or (f) usual prize contingency management with a 50% probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. The investigators expect that the new contingency management conditions will reduce cocaine use relative to the control condition, that 31% probability conditions will decrease drug use relative to 100% conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31%/7-category condition is expected to be most efficacious. Results will be instrumental for further developing prize contingency management to improve outcomes of cocaine-dependent methadone patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years
- •current DSM-IV diagnosis of cocaine dependence
- •enrolled at the clinic for >3 months
- •on a stable dose of methadone (no changes) for >1 month and not requesting a dose alteration
- •submitted >1 clinic cocaine positive sample in the last 6 months
- •English speaking
- •pass a quiz related to understanding the informed consent form
排除标准
- •serious, uncontrolled psychiatric illness
- •significant cognitive impairment
- •in recovery from pathological gambling
研究组 & 干预措施
Treatment Group A
Standard Care
Treatment Group B
100% probability of winning a prize with each draw and has 3 prize categories
干预措施: prize contingency management (Behavioral)
Treatment Group C
31% probability of winning and has 3 prize categories
干预措施: prize contingency management (Behavioral)
Treatment Group D
100% probability of winning and has 7 prize categories
干预措施: prize contingency management (Behavioral)
Treatment Group E
31% probability of winning and has 7 prize categories
干预措施: prize contingency management (Behavioral)
Treatment Group F
usual prize contingency management with a 50% probability of winning from 3 prize categories
干预措施: prize contingency management (Behavioral)
结局指标
主要结局
longest continuous period of cocaine abstinence
时间窗: three months
次要结局
未报告次要终点
研究者
Sheila Alessi
Associate Professor
UConn Health
