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临床试验/NCT01401270
NCT01401270已完成不适用

Prize Contingency Management for Cocaine-Dependent Methadone Patients

UConn Health1 个研究点 分布在 1 个国家目标入组 280 人开始时间: 2011年11月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
280
试验地点
1
主要终点
longest continuous period of cocaine abstinence

研究概览

简要总结

The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and has 3 prize categories, (c) a contingency management condition that arranges a 31% probability of winning and has 3 prize categories, (d) a contingency management condition that arranges a 100% probability of winning and has 7 prize categories, (e) a contingency management condition that arranges a 31% probability of winning and has 7 prize categories, or (f) usual prize contingency management with a 50% probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. The investigators expect that the new contingency management conditions will reduce cocaine use relative to the control condition, that 31% probability conditions will decrease drug use relative to 100% conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31%/7-category condition is expected to be most efficacious. Results will be instrumental for further developing prize contingency management to improve outcomes of cocaine-dependent methadone patients.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •age > 18 years
  • •current DSM-IV diagnosis of cocaine dependence
  • •enrolled at the clinic for >3 months
  • •on a stable dose of methadone (no changes) for >1 month and not requesting a dose alteration
  • •submitted >1 clinic cocaine positive sample in the last 6 months
  • •English speaking
  • •pass a quiz related to understanding the informed consent form

排除标准

  • •serious, uncontrolled psychiatric illness
  • •significant cognitive impairment
  • •in recovery from pathological gambling

研究组 & 干预措施

Treatment Group A

No Intervention

Standard Care

Treatment Group B

Experimental

100% probability of winning a prize with each draw and has 3 prize categories

干预措施: prize contingency management (Behavioral)

Treatment Group C

Experimental

31% probability of winning and has 3 prize categories

干预措施: prize contingency management (Behavioral)

Treatment Group D

Experimental

100% probability of winning and has 7 prize categories

干预措施: prize contingency management (Behavioral)

Treatment Group E

Experimental

31% probability of winning and has 7 prize categories

干预措施: prize contingency management (Behavioral)

Treatment Group F

Experimental

usual prize contingency management with a 50% probability of winning from 3 prize categories

干预措施: prize contingency management (Behavioral)

结局指标

主要结局

longest continuous period of cocaine abstinence

时间窗: three months

次要结局

未报告次要终点

研究者

发起方
UConn Health
申办方类型
Other
责任方
Principal Investigator
主要研究者

Sheila Alessi

Associate Professor

UConn Health

研究点 (1)

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