NCT03133169已完成不适用
Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major Children in Assiut University Children Hospital
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Erythrocyte glutamine level
研究概览
简要总结
The study will investigate the relation between erythrocyte glutamine/glutamate ratio and pulmonary hypertension risk in Egyptian thalassemic children in Assiut University Children Hospital
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Established diagnosis of Thalassemia.
- •PH risk documented by doppler echocardiography, defined as tricuspid regurge velocity (TRV) equal to or greater than 2.5 m/s
排除标准
- •Acute crisis or hospitalization within 1 month of enrollment
- •Hepatic dysfunction (SGPT greater than 3X normal)
- •Renal dysfunction (Creatinine greater than 2X normal)
- •Patients on sildenafil (Viagra), calcium channel blockers or other drugs for the control of PH.
结局指标
主要结局
Erythrocyte glutamine level
时间窗: 2 months
marker for oxidative stress
Tricuspid regurge velocity
时间窗: 2 months
Measures the risk of pulmonary hypertension
次要结局
- Ferritin level(2 months)
- Renal function tests(2 months)
- Liver function tests(2 months)
- Plasma glutamine level(2 months)
研究者
Fatma Sami
Pediatric Resident
Assiut University
研究点 (1)
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