The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations; Does Topiramat or Zonisamide Cause Metabolic Acidosis?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Intraoperative Metabolic Acidosis
研究概览
简要总结
The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations
详细描述
Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients.
Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients.
Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing intracranial surgery with craniotomy and using antiepileptic drugs
- •ASA I-III
- •Patients undergoing elective surgery
排除标准
- •Patients with a surgical procedure time of more than 5 hours
- •Patients who received more than 2 units of blood transfusion during the operation
- •Patients taking other drugs that can cause metabolic acidosis
- •Patients with diabetes mellitus, diabetes insipidus, hepatic or renal disease
结局指标
主要结局
Intraoperative Metabolic Acidosis
时间窗: during the operation
The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.
Preoperative Metabolic Acidosis
时间窗: Baseline
The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.
Postoperative Metabolic Acidosis
时间窗: Day 1
The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.
次要结局
未报告次要终点
研究者
Onur Kucuk
Department of anesthesiology and reanimation, Principal Investigator, Resident Doctor
Trakya University