NCT05204433Unknown不适用
Correlation Between Methylation Site of SFRP1 Gene Promoter and Colorectal Cancer and Adenoma
Xijing Hospital of Digestive Diseases1 个研究点 分布在 1 个国家目标入组 220 人开始时间: 2019年1月5日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 220
- 试验地点
- 1
- 主要终点
- effectiveness of methylation markers from stool samples
研究概览
简要总结
In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1_16_17_18 CpG site was good performance as a diagnostic marker of colorectal cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •consecutive adult patients undergoing an outpatient endoscopy and histopathologically diagnosed as colorectal cancer or adenoma. Also, healthy individuals were invited to be enrolled.
排除标准
- •Lynch syndrome
- •Familial adenomatous polyposis
- •MUTYH associated polyposis
- •Peutz-Jeghers syndrome
- •Juvenile polyposis syndrome
- •Serrated polyposis syndrome
结局指标
主要结局
effectiveness of methylation markers from stool samples
时间窗: 3 years
assess the effectiveness of methylation markers from stool samples in colon cancer patients, colorectal adenoma patients, compared with normal volunteers
次要结局
- assess the capacities of RF model in screening potential clinical biomarkers.(3 years)
研究者
Jie Liang
Professor
Xijing Hospital of Digestive Diseases
研究点 (1)
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